Severe sinus bradycardia after initiation of bupropion therapy: A probable drug-drug interaction with metoprolol

David L. McCollum, Jerica L. Greene, Darren K McGuire

Research output: Contribution to journalArticle

22 Scopus citations


Bupropion is an increasingly prescribed agent to aid in smoking cessation. However it has important drug-drug interactions related to the cytochrome P450 system. One of these is its inhibition of the metabolism of the commonly used beta-blocker, metoprolol. The authors describe a case of severe bradycardia related to the addition of bupropion to the medical regimen of a patient on metoprolol.

Original languageEnglish (US)
Pages (from-to)329-330
Number of pages2
JournalCardiovascular Drugs and Therapy
Issue number4
Publication statusPublished - Jul 2004



  • bradycardia
  • bupropion
  • cytochrome P450
  • metoprolol

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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