Severe sinus bradycardia after initiation of bupropion therapy: A probable drug-drug interaction with metoprolol

David L. McCollum; Jerica L. Greene; Darren K McGuire

doi:10.1023/B:CARD.0000041254.15807.98

Severe sinus bradycardia after initiation of bupropion therapy: A probable drug-drug interaction with metoprolol

David L. McCollum, Jerica L. Greene, Darren K McGuire

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Bupropion is an increasingly prescribed agent to aid in smoking cessation. However it has important drug-drug interactions related to the cytochrome P450 system. One of these is its inhibition of the metabolism of the commonly used beta-blocker, metoprolol. The authors describe a case of severe bradycardia related to the addition of bupropion to the medical regimen of a patient on metoprolol.

Original language	English (US)
Pages (from-to)	329-330
Number of pages	2
Journal	Cardiovascular Drugs and Therapy
Volume	18
Issue number	4
DOIs	https://doi.org/10.1023/B:CARD.0000041254.15807.98
State	Published - Jul 2004

Keywords

bradycardia
bupropion
cytochrome P450
metoprolol

ASJC Scopus subject areas

Pharmacology
Cardiology and Cardiovascular Medicine
Pharmacology (medical)

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10.1023/B:CARD.0000041254.15807.98

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KW - metoprolol

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Severe sinus bradycardia after initiation of bupropion therapy: A probable drug-drug interaction with metoprolol

Abstract

Keywords

ASJC Scopus subject areas

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