Severe Tumor Lysis Syndrome and Acute Pulmonary Edema Requiring Extracorporeal Membrane Oxygenation Following Initiation of Chemotherapy for Metastatic Alveolar Rhabdomyosarcoma

Ethan Sanford, Traci Wolbrink, Jennifer Mack, R. Grant Rowe

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We present an 8-year-old male with metastatic alveolar rhabdomyosarcoma (ARMS) who developed precipitous cardiopulmonary collapse with severe tumor lysis syndrome (TLS) 48 hr after initiation of chemotherapy. Despite no detectable pulmonary metastases, acute hypoxemic respiratory failure developed, requiring extracorporeal membrane oxygenation (ECMO). Although TLS has been reported in disseminated ARMS, this singular case of life-threatening respiratory deterioration developing after initiation of chemotherapy presented unique therapeutic dilemmas. We review the clinical aspects of this case, including possible mechanisms of respiratory failure, and discuss the role of ECMO utilization in pediatric oncology.

Original languageEnglish (US)
Pages (from-to)928-930
Number of pages3
JournalPediatric Blood and Cancer
Volume63
Issue number5
DOIs
StatePublished - May 1 2016
Externally publishedYes

Keywords

  • Alveolar rhabdomyosarcoma
  • ECMO
  • Pediatric cancer
  • Tumor lysis syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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