Severity of eating disorder symptoms related to oxytocin receptor polymorphisms in anorexia nervosa

Summer F. Acevedo, Celeste Valencia, Michael Lutter, Carrie J. McAdams

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Oxytocin is a peptide hormone important for social behavior and differences in psychological traits have been associated with variants of the oxytocin receptor gene in healthy people. We examined whether single nucleotide polymorphisms (SNPs) of the oxytocin receptor gene (OXTR) correlated with clinical symptoms in women with anorexia nervosa, bulimia nervosa, and healthy comparison (HC) women. Subjects completed clinical assessments and provided DNA for analysis. Subjects were divided into four groups: HC, subjects currently with anorexia nervosa (AN-C), subjects with a history of anorexia nervosa but in long-term weight recovery (AN-WR), and subjects with bulimia nervosa (BN). Five SNPs of the oxytocin receptor were examined. Minor allele carriers showed greater severity in most of the psychiatric symptoms. Importantly, the combination of having had anorexia and carrying either of the A alleles for two SNPS in the OXTR gene (rs53576, rs2254298) was associated with increased severity specifically for ED symptoms including cognitions and behaviors associated both with eating and appearance. A review of psychosocial data related to the OXTR polymorphisms examined is included in the discussion. OXTR polymorphisms may be a useful intermediate endophenotype to consider in the treatment of patients with anorexia nervosa.

Original languageEnglish (US)
Pages (from-to)641-648
Number of pages8
JournalPsychiatry Research
Volume228
Issue number3
DOIs
StatePublished - Aug 30 2015

Fingerprint

Oxytocin Receptors
Anorexia Nervosa
Genes
Bulimia Nervosa
Single Nucleotide Polymorphism
Alleles
Endophenotypes
Peptide Hormones
Social Behavior
Anorexia
Oxytocin
Cognition
Psychiatry
Feeding and Eating Disorders
Healthy Volunteers
Eating
Psychology
Weights and Measures
DNA

Keywords

  • Anorexia nervosa
  • Bulimia nervosa
  • Eating disorders
  • Oxytocin
  • Social behavior

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Severity of eating disorder symptoms related to oxytocin receptor polymorphisms in anorexia nervosa. / Acevedo, Summer F.; Valencia, Celeste; Lutter, Michael; McAdams, Carrie J.

In: Psychiatry Research, Vol. 228, No. 3, 30.08.2015, p. 641-648.

Research output: Contribution to journalArticle

Acevedo, Summer F. ; Valencia, Celeste ; Lutter, Michael ; McAdams, Carrie J. / Severity of eating disorder symptoms related to oxytocin receptor polymorphisms in anorexia nervosa. In: Psychiatry Research. 2015 ; Vol. 228, No. 3. pp. 641-648.
@article{3ec6389ee4de4ce581c62e121ad8755c,
title = "Severity of eating disorder symptoms related to oxytocin receptor polymorphisms in anorexia nervosa",
abstract = "Oxytocin is a peptide hormone important for social behavior and differences in psychological traits have been associated with variants of the oxytocin receptor gene in healthy people. We examined whether single nucleotide polymorphisms (SNPs) of the oxytocin receptor gene (OXTR) correlated with clinical symptoms in women with anorexia nervosa, bulimia nervosa, and healthy comparison (HC) women. Subjects completed clinical assessments and provided DNA for analysis. Subjects were divided into four groups: HC, subjects currently with anorexia nervosa (AN-C), subjects with a history of anorexia nervosa but in long-term weight recovery (AN-WR), and subjects with bulimia nervosa (BN). Five SNPs of the oxytocin receptor were examined. Minor allele carriers showed greater severity in most of the psychiatric symptoms. Importantly, the combination of having had anorexia and carrying either of the A alleles for two SNPS in the OXTR gene (rs53576, rs2254298) was associated with increased severity specifically for ED symptoms including cognitions and behaviors associated both with eating and appearance. A review of psychosocial data related to the OXTR polymorphisms examined is included in the discussion. OXTR polymorphisms may be a useful intermediate endophenotype to consider in the treatment of patients with anorexia nervosa.",
keywords = "Anorexia nervosa, Bulimia nervosa, Eating disorders, Oxytocin, Social behavior",
author = "Acevedo, {Summer F.} and Celeste Valencia and Michael Lutter and McAdams, {Carrie J.}",
year = "2015",
month = "8",
day = "30",
doi = "10.1016/j.psychres.2015.05.040",
language = "English (US)",
volume = "228",
pages = "641--648",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Severity of eating disorder symptoms related to oxytocin receptor polymorphisms in anorexia nervosa

AU - Acevedo, Summer F.

AU - Valencia, Celeste

AU - Lutter, Michael

AU - McAdams, Carrie J.

PY - 2015/8/30

Y1 - 2015/8/30

N2 - Oxytocin is a peptide hormone important for social behavior and differences in psychological traits have been associated with variants of the oxytocin receptor gene in healthy people. We examined whether single nucleotide polymorphisms (SNPs) of the oxytocin receptor gene (OXTR) correlated with clinical symptoms in women with anorexia nervosa, bulimia nervosa, and healthy comparison (HC) women. Subjects completed clinical assessments and provided DNA for analysis. Subjects were divided into four groups: HC, subjects currently with anorexia nervosa (AN-C), subjects with a history of anorexia nervosa but in long-term weight recovery (AN-WR), and subjects with bulimia nervosa (BN). Five SNPs of the oxytocin receptor were examined. Minor allele carriers showed greater severity in most of the psychiatric symptoms. Importantly, the combination of having had anorexia and carrying either of the A alleles for two SNPS in the OXTR gene (rs53576, rs2254298) was associated with increased severity specifically for ED symptoms including cognitions and behaviors associated both with eating and appearance. A review of psychosocial data related to the OXTR polymorphisms examined is included in the discussion. OXTR polymorphisms may be a useful intermediate endophenotype to consider in the treatment of patients with anorexia nervosa.

AB - Oxytocin is a peptide hormone important for social behavior and differences in psychological traits have been associated with variants of the oxytocin receptor gene in healthy people. We examined whether single nucleotide polymorphisms (SNPs) of the oxytocin receptor gene (OXTR) correlated with clinical symptoms in women with anorexia nervosa, bulimia nervosa, and healthy comparison (HC) women. Subjects completed clinical assessments and provided DNA for analysis. Subjects were divided into four groups: HC, subjects currently with anorexia nervosa (AN-C), subjects with a history of anorexia nervosa but in long-term weight recovery (AN-WR), and subjects with bulimia nervosa (BN). Five SNPs of the oxytocin receptor were examined. Minor allele carriers showed greater severity in most of the psychiatric symptoms. Importantly, the combination of having had anorexia and carrying either of the A alleles for two SNPS in the OXTR gene (rs53576, rs2254298) was associated with increased severity specifically for ED symptoms including cognitions and behaviors associated both with eating and appearance. A review of psychosocial data related to the OXTR polymorphisms examined is included in the discussion. OXTR polymorphisms may be a useful intermediate endophenotype to consider in the treatment of patients with anorexia nervosa.

KW - Anorexia nervosa

KW - Bulimia nervosa

KW - Eating disorders

KW - Oxytocin

KW - Social behavior

UR - http://www.scopus.com/inward/record.url?scp=84938749034&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938749034&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2015.05.040

DO - 10.1016/j.psychres.2015.05.040

M3 - Article

VL - 228

SP - 641

EP - 648

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 3

ER -