TY - JOUR
T1 - Sex, aging, and preexisting cerebral ischemic disease in patients with aortic stenosis
AU - Wang, Ping
AU - Acker, Michael A.
AU - Bilello, Michel
AU - Melhem, Elias R.
AU - Stambrook, Elizabeth
AU - Ratcliffe, Sarah J.
AU - Floyd, Thomas F.
N1 - Funding Information:
We wish to acknowledge the assistance of Abigail Lyon, BS, Sara Heverly-Fitt, BS, and Scott Welden for their contributions to the study and data organization. This study was supported by National Institutes of Health Grant No. R01HL084375 .
PY - 2010/10
Y1 - 2010/10
N2 - Background: Patients undergoing cardiac surgery have a high frequency of preexisting cerebral ischemic lesions, the presence of which appears to predict cognitive sequelae. Patients undergoing aortic valve replacement for aortic stenosis (AS) incur an exceptionally high risk for perioperative cerebral ischemia. The extreme risk in this subgroup may arise from the preexisting burden of cerebral ischemic disease. We tested the hypotheses that increasing age, female sex, coronary artery disease, and the severity of AS are predictive of the severity of preexisting cerebral ischemic lesions. Methods: A total of 95 subjects were included in this study. Subjects were imaged on 1.5 Tesla magnetic resonance imaging scanners to obtain multimodal image sets which were used for the automatic segmentation of cerebral lesion volume. The dependence of lesion volume upon age, sex, coronary artery disease, and the severity of AS were tested. Results: The results demonstrate a strong correlation between aging, female sex, and white matter and ischemia-like lesion volume in patients with aortic stenosis. Conclusions: Women and those of advanced age presenting for aortic valve replacement for AS may incur a particularly high risk for postoperative neurologic sequelae due to an exceptional preexisting burden of cerebral ischemic disease.
AB - Background: Patients undergoing cardiac surgery have a high frequency of preexisting cerebral ischemic lesions, the presence of which appears to predict cognitive sequelae. Patients undergoing aortic valve replacement for aortic stenosis (AS) incur an exceptionally high risk for perioperative cerebral ischemia. The extreme risk in this subgroup may arise from the preexisting burden of cerebral ischemic disease. We tested the hypotheses that increasing age, female sex, coronary artery disease, and the severity of AS are predictive of the severity of preexisting cerebral ischemic lesions. Methods: A total of 95 subjects were included in this study. Subjects were imaged on 1.5 Tesla magnetic resonance imaging scanners to obtain multimodal image sets which were used for the automatic segmentation of cerebral lesion volume. The dependence of lesion volume upon age, sex, coronary artery disease, and the severity of AS were tested. Results: The results demonstrate a strong correlation between aging, female sex, and white matter and ischemia-like lesion volume in patients with aortic stenosis. Conclusions: Women and those of advanced age presenting for aortic valve replacement for AS may incur a particularly high risk for postoperative neurologic sequelae due to an exceptional preexisting burden of cerebral ischemic disease.
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U2 - 10.1016/j.athoracsur.2010.04.016
DO - 10.1016/j.athoracsur.2010.04.016
M3 - Article
C2 - 20868818
AN - SCOPUS:77957156224
SN - 0003-4975
VL - 90
SP - 1230
EP - 1235
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 4
ER -