Abstract
Exercise has numerous beneficial metabolic effects. The central nervous system (CNS) is critical for regulating energy balance and coordinating whole body metabolism. However, a role for the CNS in the regulation of metabolism in the context of the exercise remains less clear. Here, using genetically engineered mice we assessed the requirement of steroidogenic factor-1 (SF-1) expression in neurons of the ventromedial hypothalamic nucleus (VMH) in mediating the beneficial effects of exercise on metabolism. We found that VMH-specific deletion of SF-1 blunts (a) the reductions in fat mass, (b) improvements in glycemia, and (c) increases in energy expenditure that are associated with exercise training. Unexpectedly, we found that SF-1 deletion in the VMH attenuates metabolic responses of skeletal muscle to exercise, including induction of PGC-1a expression. Collectively, this evidence suggests that SF-1 expression in VMH neurons is required for the beneficial effects of exercise on metabolism.
| Original language | English (US) |
|---|---|
| Article number | e18206 |
| Journal | eLife |
| Volume | 5 |
| Issue number | NOVEMBER2016 |
| DOIs | |
| State | Published - Nov 22 2016 |
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ASJC Scopus subject areas
- Neuroscience(all)
- Medicine(all)
- Immunology and Microbiology(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise. / Fujikawa, Teppei; Castorena, Carlos M.; Pearson, Mackenzie; Kusminski, Christine; Ahmed, Newaz; Battiprolu, Pavan K.; Kim, Ki Woo; Lee, Syann; Hill, Joseph A; Scherer, Philipp E; Holland, William L; Elmquist, Joel K.
In: eLife, Vol. 5, No. NOVEMBER2016, e18206, 22.11.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise
AU - Fujikawa, Teppei
AU - Castorena, Carlos M.
AU - Pearson, Mackenzie
AU - Kusminski, Christine
AU - Ahmed, Newaz
AU - Battiprolu, Pavan K.
AU - Kim, Ki Woo
AU - Lee, Syann
AU - Hill, Joseph A
AU - Scherer, Philipp E
AU - Holland, William L
AU - Elmquist, Joel K
PY - 2016/11/22
Y1 - 2016/11/22
N2 - Exercise has numerous beneficial metabolic effects. The central nervous system (CNS) is critical for regulating energy balance and coordinating whole body metabolism. However, a role for the CNS in the regulation of metabolism in the context of the exercise remains less clear. Here, using genetically engineered mice we assessed the requirement of steroidogenic factor-1 (SF-1) expression in neurons of the ventromedial hypothalamic nucleus (VMH) in mediating the beneficial effects of exercise on metabolism. We found that VMH-specific deletion of SF-1 blunts (a) the reductions in fat mass, (b) improvements in glycemia, and (c) increases in energy expenditure that are associated with exercise training. Unexpectedly, we found that SF-1 deletion in the VMH attenuates metabolic responses of skeletal muscle to exercise, including induction of PGC-1a expression. Collectively, this evidence suggests that SF-1 expression in VMH neurons is required for the beneficial effects of exercise on metabolism.
AB - Exercise has numerous beneficial metabolic effects. The central nervous system (CNS) is critical for regulating energy balance and coordinating whole body metabolism. However, a role for the CNS in the regulation of metabolism in the context of the exercise remains less clear. Here, using genetically engineered mice we assessed the requirement of steroidogenic factor-1 (SF-1) expression in neurons of the ventromedial hypothalamic nucleus (VMH) in mediating the beneficial effects of exercise on metabolism. We found that VMH-specific deletion of SF-1 blunts (a) the reductions in fat mass, (b) improvements in glycemia, and (c) increases in energy expenditure that are associated with exercise training. Unexpectedly, we found that SF-1 deletion in the VMH attenuates metabolic responses of skeletal muscle to exercise, including induction of PGC-1a expression. Collectively, this evidence suggests that SF-1 expression in VMH neurons is required for the beneficial effects of exercise on metabolism.
UR - http://www.scopus.com/inward/record.url?scp=84997079620&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84997079620&partnerID=8YFLogxK
U2 - 10.7554/eLife.18206
DO - 10.7554/eLife.18206
M3 - Article
C2 - 27874828
AN - SCOPUS:84997079620
VL - 5
JO - eLife
JF - eLife
SN - 2050-084X
IS - NOVEMBER2016
M1 - e18206
ER -