@article{706f2402c8594550ba8b0c62a425b0c3,
title = "SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise",
abstract = "Exercise has numerous beneficial metabolic effects. The central nervous system (CNS) is critical for regulating energy balance and coordinating whole body metabolism. However, a role for the CNS in the regulation of metabolism in the context of the exercise remains less clear. Here, using genetically engineered mice we assessed the requirement of steroidogenic factor-1 (SF-1) expression in neurons of the ventromedial hypothalamic nucleus (VMH) in mediating the beneficial effects of exercise on metabolism. We found that VMH-specific deletion of SF-1 blunts (a) the reductions in fat mass, (b) improvements in glycemia, and (c) increases in energy expenditure that are associated with exercise training. Unexpectedly, we found that SF-1 deletion in the VMH attenuates metabolic responses of skeletal muscle to exercise, including induction of PGC-1a expression. Collectively, this evidence suggests that SF-1 expression in VMH neurons is required for the beneficial effects of exercise on metabolism.",
author = "Teppei Fujikawa and Castorena, {Carlos M.} and Mackenzie Pearson and Christine Kusminski and Newaz Ahmed and Battiprolu, {Pavan K.} and Kim, {Ki Woo} and Syann Lee and Hill, {Joseph A} and Scherer, {Philipp E} and Holland, {William L} and Elmquist, {Joel K}",
note = "Funding Information: National Institute of Diabetes and Digestive and Kidney Diseases R00DK094973 Teppei Fujikawa. American Heart Association 14SDG17950008 Carlos M Castorena National Research Foundation of Korea NRF-2013R1A1A1007693 Ki Woo Kim. Cancer Prevention and Research Institute of Texas RP110486P3 Joseph A Hill. Fondation Leducq 11CVD04 Joseph A Hill. National Heart, Lung, and Blood Institute HL-120732 Joseph A Hill. National Institute of Diabetes and Digestive and Kidney Diseases R01 DK100659 Joseph A Hill. National Institute of Diabetes and Digestive and Kidney Diseases P01 DK088761 Joseph A Hill. American Heart Association 14SFRN20740000 Philipp E Scherer, Joel K Elmquist. National Heart, Lung, and Blood Institute HL-100401 William L Holland. National Institute of Diabetes and Digestive and Kidney Diseases F32 DK104659 Joel K Elmquist. National Institute of Diabetes and Digestive and Kidney Diseases DK100659 Joel K Elmquist. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.",
year = "2016",
month = nov,
day = "22",
doi = "10.7554/eLife.18206",
language = "English (US)",
volume = "5",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
number = "NOVEMBER2016",
}