SF-1 in the ventral medial hypothalamic nucleus: A key regulator of homeostasis

Ki Woo Kim, Jong Woo Sohn, Daisuke Kohno, Yong Xu, Kevin Williams, Joel K. Elmquist

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

The ventral medial hypothalamic nucleus (VMH) regulates food intake and body weight homeostasis. The nuclear receptor NR5A1 (steroidogenic factor 1; SF-1) is a transcription factor whose expression is highly restricted in the VMH and is required for the development of the nucleus. Neurons expressing SF-1 in the VMH have emerged as playing important roles in the regulation of body weight and energy homeostasis. Many of these studies have used site-specific gene KO approaches, providing insights into the molecular mechanisms underlying the regulation of energy homeostasis by the SF-1 neurons of the VMH. In this brief review, we will focus on recent studies defining the molecular mechanisms regulating energy homeostasis and body weight in the VMH, particularly stressing the SF-1 expressing neurons.

Original languageEnglish (US)
Pages (from-to)219-223
Number of pages5
JournalMolecular and Cellular Endocrinology
Volume336
Issue number1-2
DOIs
StatePublished - Apr 10 2011

Keywords

  • Arcuate nucleus of the hypothalamus (ARH)
  • Diet-induced obesity
  • Dorsomedial hypothalamic nucleus (DMH)
  • Energy homeostasis
  • Steroidogenic factor 1 (SF-1)
  • Ventral medial nucleus of the hypothalamus (VMH)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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