SF-1 in the ventral medial hypothalamic nucleus

A key regulator of homeostasis

Ki Woo Kim, Jong Woo Sohn, Daisuke Kohno, Yong Xu, Kevin Williams, Joel K. Elmquist

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The ventral medial hypothalamic nucleus (VMH) regulates food intake and body weight homeostasis. The nuclear receptor NR5A1 (steroidogenic factor 1; SF-1) is a transcription factor whose expression is highly restricted in the VMH and is required for the development of the nucleus. Neurons expressing SF-1 in the VMH have emerged as playing important roles in the regulation of body weight and energy homeostasis. Many of these studies have used site-specific gene KO approaches, providing insights into the molecular mechanisms underlying the regulation of energy homeostasis by the SF-1 neurons of the VMH. In this brief review, we will focus on recent studies defining the molecular mechanisms regulating energy homeostasis and body weight in the VMH, particularly stressing the SF-1 expressing neurons.

Original languageEnglish (US)
Pages (from-to)219-223
Number of pages5
JournalMolecular and Cellular Endocrinology
Volume336
Issue number1-2
DOIs
StatePublished - Apr 10 2011

Fingerprint

Neurons
Homeostasis
Body Weight
Steroidogenic Factor 1
Cytoplasmic and Nuclear Receptors
Transcription Factors
Genes
Eating

Keywords

  • Arcuate nucleus of the hypothalamus (ARH)
  • Diet-induced obesity
  • Dorsomedial hypothalamic nucleus (DMH)
  • Energy homeostasis
  • Steroidogenic factor 1 (SF-1)
  • Ventral medial nucleus of the hypothalamus (VMH)

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

Cite this

SF-1 in the ventral medial hypothalamic nucleus : A key regulator of homeostasis. / Kim, Ki Woo; Sohn, Jong Woo; Kohno, Daisuke; Xu, Yong; Williams, Kevin; Elmquist, Joel K.

In: Molecular and Cellular Endocrinology, Vol. 336, No. 1-2, 10.04.2011, p. 219-223.

Research output: Contribution to journalArticle

Kim, Ki Woo ; Sohn, Jong Woo ; Kohno, Daisuke ; Xu, Yong ; Williams, Kevin ; Elmquist, Joel K. / SF-1 in the ventral medial hypothalamic nucleus : A key regulator of homeostasis. In: Molecular and Cellular Endocrinology. 2011 ; Vol. 336, No. 1-2. pp. 219-223.
@article{de8fa82c02aa4e20a27610d559f66310,
title = "SF-1 in the ventral medial hypothalamic nucleus: A key regulator of homeostasis",
abstract = "The ventral medial hypothalamic nucleus (VMH) regulates food intake and body weight homeostasis. The nuclear receptor NR5A1 (steroidogenic factor 1; SF-1) is a transcription factor whose expression is highly restricted in the VMH and is required for the development of the nucleus. Neurons expressing SF-1 in the VMH have emerged as playing important roles in the regulation of body weight and energy homeostasis. Many of these studies have used site-specific gene KO approaches, providing insights into the molecular mechanisms underlying the regulation of energy homeostasis by the SF-1 neurons of the VMH. In this brief review, we will focus on recent studies defining the molecular mechanisms regulating energy homeostasis and body weight in the VMH, particularly stressing the SF-1 expressing neurons.",
keywords = "Arcuate nucleus of the hypothalamus (ARH), Diet-induced obesity, Dorsomedial hypothalamic nucleus (DMH), Energy homeostasis, Steroidogenic factor 1 (SF-1), Ventral medial nucleus of the hypothalamus (VMH)",
author = "Kim, {Ki Woo} and Sohn, {Jong Woo} and Daisuke Kohno and Yong Xu and Kevin Williams and Elmquist, {Joel K.}",
year = "2011",
month = "4",
day = "10",
doi = "10.1016/j.mce.2010.11.019",
language = "English (US)",
volume = "336",
pages = "219--223",
journal = "Molecular and Cellular Endocrinology",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - SF-1 in the ventral medial hypothalamic nucleus

T2 - A key regulator of homeostasis

AU - Kim, Ki Woo

AU - Sohn, Jong Woo

AU - Kohno, Daisuke

AU - Xu, Yong

AU - Williams, Kevin

AU - Elmquist, Joel K.

PY - 2011/4/10

Y1 - 2011/4/10

N2 - The ventral medial hypothalamic nucleus (VMH) regulates food intake and body weight homeostasis. The nuclear receptor NR5A1 (steroidogenic factor 1; SF-1) is a transcription factor whose expression is highly restricted in the VMH and is required for the development of the nucleus. Neurons expressing SF-1 in the VMH have emerged as playing important roles in the regulation of body weight and energy homeostasis. Many of these studies have used site-specific gene KO approaches, providing insights into the molecular mechanisms underlying the regulation of energy homeostasis by the SF-1 neurons of the VMH. In this brief review, we will focus on recent studies defining the molecular mechanisms regulating energy homeostasis and body weight in the VMH, particularly stressing the SF-1 expressing neurons.

AB - The ventral medial hypothalamic nucleus (VMH) regulates food intake and body weight homeostasis. The nuclear receptor NR5A1 (steroidogenic factor 1; SF-1) is a transcription factor whose expression is highly restricted in the VMH and is required for the development of the nucleus. Neurons expressing SF-1 in the VMH have emerged as playing important roles in the regulation of body weight and energy homeostasis. Many of these studies have used site-specific gene KO approaches, providing insights into the molecular mechanisms underlying the regulation of energy homeostasis by the SF-1 neurons of the VMH. In this brief review, we will focus on recent studies defining the molecular mechanisms regulating energy homeostasis and body weight in the VMH, particularly stressing the SF-1 expressing neurons.

KW - Arcuate nucleus of the hypothalamus (ARH)

KW - Diet-induced obesity

KW - Dorsomedial hypothalamic nucleus (DMH)

KW - Energy homeostasis

KW - Steroidogenic factor 1 (SF-1)

KW - Ventral medial nucleus of the hypothalamus (VMH)

UR - http://www.scopus.com/inward/record.url?scp=79952068857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952068857&partnerID=8YFLogxK

U2 - 10.1016/j.mce.2010.11.019

DO - 10.1016/j.mce.2010.11.019

M3 - Article

VL - 336

SP - 219

EP - 223

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

IS - 1-2

ER -