Shc and the mechanotransduction of cellular anchorage and metastasis

Research output: Contribution to journalReview article

Abstract

Tissue cells continually monitor anchorage conditions by gauging the physical properties of their underlying matrix and surrounding environment. The Rho and Ras GTPases are essential components of these mechanosensory pathways. These molecular switches control both cytoskeletal as well as cell fate responses to anchorage conditions and are thus critical to our understanding of how cells respond to their physical environment and, by extension, how malignant cells gainsay these regulatory pathways. Recent studies indicate that 2 proteins produced by the SHC1 gene, thought for the most part to functionally oppose each other, collaborate in their ability to respond to mechanical force by initiating respective Rho and Ras signals. In this review, we focus on the coupling of Shc and GTPases in the cellular response to mechanical anchorage signals, with emphasis on its relevance for cancer.

Original languageEnglish (US)
Pages (from-to)64-71
Number of pages8
JournalSmall GTPases
Volume10
Issue number1
DOIs
StatePublished - Jan 2 2019

Fingerprint

Cellular Mechanotransduction
ras Proteins
rho GTP-Binding Proteins
Gaging
GTP Phosphohydrolases
Physical properties
Genes
Switches
Tissue
Neoplasm Metastasis
Proteins
Neoplasms

Keywords

  • Aiolos
  • Anoikis
  • cancer
  • cellular anchorage
  • focal adhesion kinase (FAK)GEF-H1
  • matrix
  • metastasis
  • p115-RhoGEF
  • p52Shc
  • p66Shc
  • Ras
  • RhoA
  • Shc

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Shc and the mechanotransduction of cellular anchorage and metastasis. / Terada, Lance S.

In: Small GTPases, Vol. 10, No. 1, 02.01.2019, p. 64-71.

Research output: Contribution to journalReview article

@article{41b82d579e594d0cafacd681c451bee4,
title = "Shc and the mechanotransduction of cellular anchorage and metastasis",
abstract = "Tissue cells continually monitor anchorage conditions by gauging the physical properties of their underlying matrix and surrounding environment. The Rho and Ras GTPases are essential components of these mechanosensory pathways. These molecular switches control both cytoskeletal as well as cell fate responses to anchorage conditions and are thus critical to our understanding of how cells respond to their physical environment and, by extension, how malignant cells gainsay these regulatory pathways. Recent studies indicate that 2 proteins produced by the SHC1 gene, thought for the most part to functionally oppose each other, collaborate in their ability to respond to mechanical force by initiating respective Rho and Ras signals. In this review, we focus on the coupling of Shc and GTPases in the cellular response to mechanical anchorage signals, with emphasis on its relevance for cancer.",
keywords = "Aiolos, Anoikis, cancer, cellular anchorage, focal adhesion kinase (FAK)GEF-H1, matrix, metastasis, p115-RhoGEF, p52Shc, p66Shc, Ras, RhoA, Shc",
author = "Terada, {Lance S}",
year = "2019",
month = "1",
day = "2",
doi = "10.1080/21541248.2016.1273172",
language = "English (US)",
volume = "10",
pages = "64--71",
journal = "Small GTPases",
issn = "2154-1248",
publisher = "Landes Bioscience",
number = "1",

}

TY - JOUR

T1 - Shc and the mechanotransduction of cellular anchorage and metastasis

AU - Terada, Lance S

PY - 2019/1/2

Y1 - 2019/1/2

N2 - Tissue cells continually monitor anchorage conditions by gauging the physical properties of their underlying matrix and surrounding environment. The Rho and Ras GTPases are essential components of these mechanosensory pathways. These molecular switches control both cytoskeletal as well as cell fate responses to anchorage conditions and are thus critical to our understanding of how cells respond to their physical environment and, by extension, how malignant cells gainsay these regulatory pathways. Recent studies indicate that 2 proteins produced by the SHC1 gene, thought for the most part to functionally oppose each other, collaborate in their ability to respond to mechanical force by initiating respective Rho and Ras signals. In this review, we focus on the coupling of Shc and GTPases in the cellular response to mechanical anchorage signals, with emphasis on its relevance for cancer.

AB - Tissue cells continually monitor anchorage conditions by gauging the physical properties of their underlying matrix and surrounding environment. The Rho and Ras GTPases are essential components of these mechanosensory pathways. These molecular switches control both cytoskeletal as well as cell fate responses to anchorage conditions and are thus critical to our understanding of how cells respond to their physical environment and, by extension, how malignant cells gainsay these regulatory pathways. Recent studies indicate that 2 proteins produced by the SHC1 gene, thought for the most part to functionally oppose each other, collaborate in their ability to respond to mechanical force by initiating respective Rho and Ras signals. In this review, we focus on the coupling of Shc and GTPases in the cellular response to mechanical anchorage signals, with emphasis on its relevance for cancer.

KW - Aiolos

KW - Anoikis

KW - cancer

KW - cellular anchorage

KW - focal adhesion kinase (FAK)GEF-H1

KW - matrix

KW - metastasis

KW - p115-RhoGEF

KW - p52Shc

KW - p66Shc

KW - Ras

KW - RhoA

KW - Shc

UR - http://www.scopus.com/inward/record.url?scp=85059066811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059066811&partnerID=8YFLogxK

U2 - 10.1080/21541248.2016.1273172

DO - 10.1080/21541248.2016.1273172

M3 - Review article

C2 - 28632027

AN - SCOPUS:85059066811

VL - 10

SP - 64

EP - 71

JO - Small GTPases

JF - Small GTPases

SN - 2154-1248

IS - 1

ER -