TY - JOUR
T1 - Short report
T2 - TH2 immune response in patients with dengue during defervescence: Preliminary evidence
AU - Mabalirajan, Ulaganathan
AU - Kadhiravan, Tamilarasu
AU - Sharma, S. K.
AU - Banga, Amit
AU - Ghosh, Balaram
PY - 2005/6
Y1 - 2005/6
N2 - A shift from a TH1 to a TH2 immune response has been observed in vitro during dengue virus infection. Estimation of plasma IgE level (n = 28), CD4:CD8 lymphocyte ratio, and the intracellular interferon-γ (IFN-γ):interleukin-4 (IL-4) ratio (n = 9) was conducted in patients with various severities of dengue around the time of defervescence. The CD4:CD8 lymphocyte ratio was significantly lower (median = 0.45, interquartile range [IQR] = 0.4-0.47 versus 1.3,1.0-1.9; P = 0.001), and IgE levels were significantly higher (mean = 300.4, SD = 252.5 versus 143.7, 117.9 IU/mL; P = 0.004) in patients than in healthy controls. The intracellular IFN-γ:IL-4 ratio was significantly lower in patients compared with controls (0.28, 0.13 versus 0.99, 0.4; P = 0.001). These findings suggest that a TH2 immune response occurs in patients with dengue around the time of defervescence.
AB - A shift from a TH1 to a TH2 immune response has been observed in vitro during dengue virus infection. Estimation of plasma IgE level (n = 28), CD4:CD8 lymphocyte ratio, and the intracellular interferon-γ (IFN-γ):interleukin-4 (IL-4) ratio (n = 9) was conducted in patients with various severities of dengue around the time of defervescence. The CD4:CD8 lymphocyte ratio was significantly lower (median = 0.45, interquartile range [IQR] = 0.4-0.47 versus 1.3,1.0-1.9; P = 0.001), and IgE levels were significantly higher (mean = 300.4, SD = 252.5 versus 143.7, 117.9 IU/mL; P = 0.004) in patients than in healthy controls. The intracellular IFN-γ:IL-4 ratio was significantly lower in patients compared with controls (0.28, 0.13 versus 0.99, 0.4; P = 0.001). These findings suggest that a TH2 immune response occurs in patients with dengue around the time of defervescence.
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U2 - 10.4269/ajtmh.2005.72.783
DO - 10.4269/ajtmh.2005.72.783
M3 - Article
C2 - 15964963
AN - SCOPUS:23844535899
SN - 0002-9637
VL - 72
SP - 783
EP - 785
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 6
ER -