Short report: TH2 immune response in patients with dengue during defervescence: Preliminary evidence

Ulaganathan Mabalirajan, Tamilarasu Kadhiravan, S. K. Sharma, Amit Banga, Balaram Ghosh

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

A shift from a TH1 to a TH2 immune response has been observed in vitro during dengue virus infection. Estimation of plasma IgE level (n = 28), CD4:CD8 lymphocyte ratio, and the intracellular interferon-γ (IFN-γ):interleukin-4 (IL-4) ratio (n = 9) was conducted in patients with various severities of dengue around the time of defervescence. The CD4:CD8 lymphocyte ratio was significantly lower (median = 0.45, interquartile range [IQR] = 0.4-0.47 versus 1.3,1.0-1.9; P = 0.001), and IgE levels were significantly higher (mean = 300.4, SD = 252.5 versus 143.7, 117.9 IU/mL; P = 0.004) in patients than in healthy controls. The intracellular IFN-γ:IL-4 ratio was significantly lower in patients compared with controls (0.28, 0.13 versus 0.99, 0.4; P = 0.001). These findings suggest that a TH2 immune response occurs in patients with dengue around the time of defervescence.

Original languageEnglish (US)
Pages (from-to)783-785
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume72
Issue number6
StatePublished - Jun 1 2005

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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