Short term oral minocycline treatment of meibomianitis

J. D. Aronowicz, W. E. Shine, D. Oral, J. M. Vargas, J. P. McCulley

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Aim: To evaluate the clinical impact, aqueous tear parameters, and meibomian gland morphology in patients with primary meibomianitis before, during, and 3 months after a course of oral minocycline. Methods: 16 patients were prospectively enrolled, 11 male and five female (mean age 69 years old). Each patient received routine clinical evaluations before, after 3 months therapy, and at 6 month study follow up visit. The clinical appearance, tear volume, flow and turnover, evaporation, Schirmer I test, meibomian gland dropout, lissamine green staining, and bacteriology wer evaluated. Results: Improvement was observed in clinical signs of meibomianitis at the second and third visits. Microbial culture findings improved. Decreased aqueous tear volume and flow, and increased evaporation rate range at 35-45% relative humidity (RH) (p<0.05) were also detected. Other related tear parameters did not change. Meibomian gland dropout showed no improvement. Conclusions: 3 months of oral minocycline resulted in clinical improvements in all meibomianitis signs that persisted for at least 3 months after discontinuation despite decreased aqueous tear volume and flow with increased evaporation (35-45% RH). However, there was improvement in the turbidity of secretions. Short term minocycline therapy probably has efficacy in the management of meibomianitis that extends beyond eradication of bacteria.

Original languageEnglish (US)
Pages (from-to)856-860
Number of pages5
JournalBritish Journal of Ophthalmology
Volume90
Issue number7
DOIs
StatePublished - Jul 2006

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Minocycline
Tears
Meibomian Glands
Humidity
Therapeutics
Bacteriology
Staining and Labeling
Bacteria

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Short term oral minocycline treatment of meibomianitis. / Aronowicz, J. D.; Shine, W. E.; Oral, D.; Vargas, J. M.; McCulley, J. P.

In: British Journal of Ophthalmology, Vol. 90, No. 7, 07.2006, p. 856-860.

Research output: Contribution to journalArticle

Aronowicz, J. D. ; Shine, W. E. ; Oral, D. ; Vargas, J. M. ; McCulley, J. P. / Short term oral minocycline treatment of meibomianitis. In: British Journal of Ophthalmology. 2006 ; Vol. 90, No. 7. pp. 856-860.
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