Short-term outcomes for lung cancer resection surgery in HIV infection

Keith M. Sigel, Kimberly Stone, Juan P. Wisnivesky, Lesley S. Park, Chung Yin Kong, Michael J. Silverberg, Sheldon Brown, Matthew Goetz, Maria C. Rodriguez-Barradas, Cynthia Gibert, Fatma Shebl, Roger J Bedimo, Roxanne Wadia, Joseph King, Kristina Crothers

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Lung cancer is the leading cause of cancer death in people living with HIV (PWH). Surgical resection is a key component of potentially curative treatment regimens for early-stage lung cancers, but its safety is unclear in the setting of HIV. From a national cohort, we assessed potential differences in the risk of major lung cancer surgery complications by HIV status. DESIGN: We linked clinical and cancer data from the Veterans Aging Cohort Study (VACS) and Veterans Affairs Corporate Data Warehouse to outcomes from the Veterans Affairs Surgical Quality Improvement Program (VASQIP) and identified 8371 patients (137 PWH, 8234 uninfected) who underwent lung cancer surgeries between 2000 and 2016. METHODS: We compared rates of 15 major short-term surgical complications by HIV status. RESULTS: Use of surgical resection for early-stage lung cancer did not differ by HIV status. Lung cancer surgery postoperative (30-day) mortality was 2.0% for PWH and did not differ by HIV status (P = 0.9). Pneumonia was the most common complication for both PWH and uninfected veterans, but did not differ significantly in prevalence between groups (11.0% for PWH versus 9.4%; P = 0.5). The frequency of complications did not differ by HIV status for any complication (all P > 0.3). There were no significant predictors of postoperative complications for PWH. CONCLUSIONS: In a national antiretroviral-era cohort of lung cancer patients undergoing surgical lung resection, short-term outcomes after surgery did not differ significantly by HIV status. Concerns regarding short-term surgical complications should have limited influence on treatment decisions for PWH with lung cancer.

Original languageEnglish (US)
Pages (from-to)1353-1360
Number of pages8
JournalAIDS (London, England)
Volume33
Issue number8
DOIs
StatePublished - Jul 1 2019

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HIV Infections
Lung Neoplasms
HIV
Veterans
Quality Improvement
Cause of Death
Neoplasms
Pneumonia
Cohort Studies
Safety

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Sigel, K. M., Stone, K., Wisnivesky, J. P., Park, L. S., Kong, C. Y., Silverberg, M. J., ... Crothers, K. (2019). Short-term outcomes for lung cancer resection surgery in HIV infection. AIDS (London, England), 33(8), 1353-1360. https://doi.org/10.1097/QAD.0000000000002200

Short-term outcomes for lung cancer resection surgery in HIV infection. / Sigel, Keith M.; Stone, Kimberly; Wisnivesky, Juan P.; Park, Lesley S.; Kong, Chung Yin; Silverberg, Michael J.; Brown, Sheldon; Goetz, Matthew; Rodriguez-Barradas, Maria C.; Gibert, Cynthia; Shebl, Fatma; Bedimo, Roger J; Wadia, Roxanne; King, Joseph; Crothers, Kristina.

In: AIDS (London, England), Vol. 33, No. 8, 01.07.2019, p. 1353-1360.

Research output: Contribution to journalArticle

Sigel, KM, Stone, K, Wisnivesky, JP, Park, LS, Kong, CY, Silverberg, MJ, Brown, S, Goetz, M, Rodriguez-Barradas, MC, Gibert, C, Shebl, F, Bedimo, RJ, Wadia, R, King, J & Crothers, K 2019, 'Short-term outcomes for lung cancer resection surgery in HIV infection', AIDS (London, England), vol. 33, no. 8, pp. 1353-1360. https://doi.org/10.1097/QAD.0000000000002200
Sigel KM, Stone K, Wisnivesky JP, Park LS, Kong CY, Silverberg MJ et al. Short-term outcomes for lung cancer resection surgery in HIV infection. AIDS (London, England). 2019 Jul 1;33(8):1353-1360. https://doi.org/10.1097/QAD.0000000000002200
Sigel, Keith M. ; Stone, Kimberly ; Wisnivesky, Juan P. ; Park, Lesley S. ; Kong, Chung Yin ; Silverberg, Michael J. ; Brown, Sheldon ; Goetz, Matthew ; Rodriguez-Barradas, Maria C. ; Gibert, Cynthia ; Shebl, Fatma ; Bedimo, Roger J ; Wadia, Roxanne ; King, Joseph ; Crothers, Kristina. / Short-term outcomes for lung cancer resection surgery in HIV infection. In: AIDS (London, England). 2019 ; Vol. 33, No. 8. pp. 1353-1360.
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abstract = "OBJECTIVE: Lung cancer is the leading cause of cancer death in people living with HIV (PWH). Surgical resection is a key component of potentially curative treatment regimens for early-stage lung cancers, but its safety is unclear in the setting of HIV. From a national cohort, we assessed potential differences in the risk of major lung cancer surgery complications by HIV status. DESIGN: We linked clinical and cancer data from the Veterans Aging Cohort Study (VACS) and Veterans Affairs Corporate Data Warehouse to outcomes from the Veterans Affairs Surgical Quality Improvement Program (VASQIP) and identified 8371 patients (137 PWH, 8234 uninfected) who underwent lung cancer surgeries between 2000 and 2016. METHODS: We compared rates of 15 major short-term surgical complications by HIV status. RESULTS: Use of surgical resection for early-stage lung cancer did not differ by HIV status. Lung cancer surgery postoperative (30-day) mortality was 2.0{\%} for PWH and did not differ by HIV status (P = 0.9). Pneumonia was the most common complication for both PWH and uninfected veterans, but did not differ significantly in prevalence between groups (11.0{\%} for PWH versus 9.4{\%}; P = 0.5). The frequency of complications did not differ by HIV status for any complication (all P > 0.3). There were no significant predictors of postoperative complications for PWH. CONCLUSIONS: In a national antiretroviral-era cohort of lung cancer patients undergoing surgical lung resection, short-term outcomes after surgery did not differ significantly by HIV status. Concerns regarding short-term surgical complications should have limited influence on treatment decisions for PWH with lung cancer.",
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AU - Sigel, Keith M.

AU - Stone, Kimberly

AU - Wisnivesky, Juan P.

AU - Park, Lesley S.

AU - Kong, Chung Yin

AU - Silverberg, Michael J.

AU - Brown, Sheldon

AU - Goetz, Matthew

AU - Rodriguez-Barradas, Maria C.

AU - Gibert, Cynthia

AU - Shebl, Fatma

AU - Bedimo, Roger J

AU - Wadia, Roxanne

AU - King, Joseph

AU - Crothers, Kristina

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N2 - OBJECTIVE: Lung cancer is the leading cause of cancer death in people living with HIV (PWH). Surgical resection is a key component of potentially curative treatment regimens for early-stage lung cancers, but its safety is unclear in the setting of HIV. From a national cohort, we assessed potential differences in the risk of major lung cancer surgery complications by HIV status. DESIGN: We linked clinical and cancer data from the Veterans Aging Cohort Study (VACS) and Veterans Affairs Corporate Data Warehouse to outcomes from the Veterans Affairs Surgical Quality Improvement Program (VASQIP) and identified 8371 patients (137 PWH, 8234 uninfected) who underwent lung cancer surgeries between 2000 and 2016. METHODS: We compared rates of 15 major short-term surgical complications by HIV status. RESULTS: Use of surgical resection for early-stage lung cancer did not differ by HIV status. Lung cancer surgery postoperative (30-day) mortality was 2.0% for PWH and did not differ by HIV status (P = 0.9). Pneumonia was the most common complication for both PWH and uninfected veterans, but did not differ significantly in prevalence between groups (11.0% for PWH versus 9.4%; P = 0.5). The frequency of complications did not differ by HIV status for any complication (all P > 0.3). There were no significant predictors of postoperative complications for PWH. CONCLUSIONS: In a national antiretroviral-era cohort of lung cancer patients undergoing surgical lung resection, short-term outcomes after surgery did not differ significantly by HIV status. Concerns regarding short-term surgical complications should have limited influence on treatment decisions for PWH with lung cancer.

AB - OBJECTIVE: Lung cancer is the leading cause of cancer death in people living with HIV (PWH). Surgical resection is a key component of potentially curative treatment regimens for early-stage lung cancers, but its safety is unclear in the setting of HIV. From a national cohort, we assessed potential differences in the risk of major lung cancer surgery complications by HIV status. DESIGN: We linked clinical and cancer data from the Veterans Aging Cohort Study (VACS) and Veterans Affairs Corporate Data Warehouse to outcomes from the Veterans Affairs Surgical Quality Improvement Program (VASQIP) and identified 8371 patients (137 PWH, 8234 uninfected) who underwent lung cancer surgeries between 2000 and 2016. METHODS: We compared rates of 15 major short-term surgical complications by HIV status. RESULTS: Use of surgical resection for early-stage lung cancer did not differ by HIV status. Lung cancer surgery postoperative (30-day) mortality was 2.0% for PWH and did not differ by HIV status (P = 0.9). Pneumonia was the most common complication for both PWH and uninfected veterans, but did not differ significantly in prevalence between groups (11.0% for PWH versus 9.4%; P = 0.5). The frequency of complications did not differ by HIV status for any complication (all P > 0.3). There were no significant predictors of postoperative complications for PWH. CONCLUSIONS: In a national antiretroviral-era cohort of lung cancer patients undergoing surgical lung resection, short-term outcomes after surgery did not differ significantly by HIV status. Concerns regarding short-term surgical complications should have limited influence on treatment decisions for PWH with lung cancer.

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