Short term versus continuous antimicrobial therapy for asymptomatic bacteriuria in pregnancy

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Abstract

Asymptomatic bacteriuria was identified in 300 pregnant women prior to the 28th wk of gestation. In 1 group of 200 women short term treatment with either nitrofurantoin or sulfamethizole was given for 14 days, and in another group of 100 women continuous therapy with 1 of these drugs was given for the remainder of gestation. Weekly urine cultures were obtained from all the women. Of the women treated with short term therapy, 65% were abacteriuric for the remainder of pregnancy following 1 course of therapy, 24% became abacteriuric but subsequently relapsed, 2% had reinfection after becoming abacteriuric, and 9% demonstrated no response. Following treatment with a second course of short term therapy, another 19% of these women were cured for the remainder of their pregnancy, and 3.5% responded to a third course. In the continuous therapy group, 88% of the women became abacteriuric for the remainder of the gestation, 3% demonstrated relapse, 2% developed reinfection, and 7% had no response to the first drug given. These data demonstrate that short term administration of antimicrobials, when combined with surveillance for recurrent bacteriuria, is effective for the management of the pregnant woman with asymptomatic bacteriuria.

Original languageEnglish (US)
Pages (from-to)262-265
Number of pages4
JournalObstetrics and Gynecology
Volume49
Issue number3
StatePublished - 1977

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Bacteriuria
Pregnancy
Pregnant Women
Sulfamethizole
Therapeutics
Nitrofurantoin
Group Psychotherapy
Pharmaceutical Preparations
Curriculum
Urine
Recurrence

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

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title = "Short term versus continuous antimicrobial therapy for asymptomatic bacteriuria in pregnancy",
abstract = "Asymptomatic bacteriuria was identified in 300 pregnant women prior to the 28th wk of gestation. In 1 group of 200 women short term treatment with either nitrofurantoin or sulfamethizole was given for 14 days, and in another group of 100 women continuous therapy with 1 of these drugs was given for the remainder of gestation. Weekly urine cultures were obtained from all the women. Of the women treated with short term therapy, 65{\%} were abacteriuric for the remainder of pregnancy following 1 course of therapy, 24{\%} became abacteriuric but subsequently relapsed, 2{\%} had reinfection after becoming abacteriuric, and 9{\%} demonstrated no response. Following treatment with a second course of short term therapy, another 19{\%} of these women were cured for the remainder of their pregnancy, and 3.5{\%} responded to a third course. In the continuous therapy group, 88{\%} of the women became abacteriuric for the remainder of the gestation, 3{\%} demonstrated relapse, 2{\%} developed reinfection, and 7{\%} had no response to the first drug given. These data demonstrate that short term administration of antimicrobials, when combined with surveillance for recurrent bacteriuria, is effective for the management of the pregnant woman with asymptomatic bacteriuria.",
author = "Whalley, {P. J.} and Cunningham, {F. G.}",
year = "1977",
language = "English (US)",
volume = "49",
pages = "262--265",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "3",

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TY - JOUR

T1 - Short term versus continuous antimicrobial therapy for asymptomatic bacteriuria in pregnancy

AU - Whalley, P. J.

AU - Cunningham, F. G.

PY - 1977

Y1 - 1977

N2 - Asymptomatic bacteriuria was identified in 300 pregnant women prior to the 28th wk of gestation. In 1 group of 200 women short term treatment with either nitrofurantoin or sulfamethizole was given for 14 days, and in another group of 100 women continuous therapy with 1 of these drugs was given for the remainder of gestation. Weekly urine cultures were obtained from all the women. Of the women treated with short term therapy, 65% were abacteriuric for the remainder of pregnancy following 1 course of therapy, 24% became abacteriuric but subsequently relapsed, 2% had reinfection after becoming abacteriuric, and 9% demonstrated no response. Following treatment with a second course of short term therapy, another 19% of these women were cured for the remainder of their pregnancy, and 3.5% responded to a third course. In the continuous therapy group, 88% of the women became abacteriuric for the remainder of the gestation, 3% demonstrated relapse, 2% developed reinfection, and 7% had no response to the first drug given. These data demonstrate that short term administration of antimicrobials, when combined with surveillance for recurrent bacteriuria, is effective for the management of the pregnant woman with asymptomatic bacteriuria.

AB - Asymptomatic bacteriuria was identified in 300 pregnant women prior to the 28th wk of gestation. In 1 group of 200 women short term treatment with either nitrofurantoin or sulfamethizole was given for 14 days, and in another group of 100 women continuous therapy with 1 of these drugs was given for the remainder of gestation. Weekly urine cultures were obtained from all the women. Of the women treated with short term therapy, 65% were abacteriuric for the remainder of pregnancy following 1 course of therapy, 24% became abacteriuric but subsequently relapsed, 2% had reinfection after becoming abacteriuric, and 9% demonstrated no response. Following treatment with a second course of short term therapy, another 19% of these women were cured for the remainder of their pregnancy, and 3.5% responded to a third course. In the continuous therapy group, 88% of the women became abacteriuric for the remainder of the gestation, 3% demonstrated relapse, 2% developed reinfection, and 7% had no response to the first drug given. These data demonstrate that short term administration of antimicrobials, when combined with surveillance for recurrent bacteriuria, is effective for the management of the pregnant woman with asymptomatic bacteriuria.

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