Siderotic nodules at MR imaging: Regenerative or dysplastic?

Glenn A. Krinsky, Vivian S. Lee, Minh T. Nguyen, Neil M. Rofsky, Neil D. Theise, Glyn R. Morgan, Lewis W. Teperman, Jeffrey C. Weinreb

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objective: To determine if iron containing "siderotic" nodules detected at magnetic resonance (MR) imaging are regenerative (RN) or dysplastic (DN) and to attempt to identify features that may distinguish them. Material and Methods: MR imaging (1.5 T) was performed on 77 cirrhotic patients who underwent orthotopic liver transplantation within 0-117 days (mean 30 days) of MR imaging. Two readers retrospectively evaluated breath-hold gradient-echo pulse sequences (echo time ≥9.0 ms, flip angle ≤45°) for the presence of hypointense nodules, which were classified as micronodular (≥3 mm), macronodular (>3 mm), or mixed. Nodule distribution was classified as focal (<5), scattered (5-20), or diffuse (>20) per slice. Thin section pathologic correlation was available in all cases, and Prussian blue iron stains were performed. Results: Of 35 patients with pathologically proven siderotic nodules, 10 (29%) had at least 2 siderotic DN. MR detected siderotic nodules in 10 of 10 (100%) patients with siderotic DN and RN, and in 18 of 25 patients (72%) with siderotic RN only. Conclusion: Siderotic RN cannot be reliably distinguished from siderotic DN with MR imaging, and therefore the widely used term "siderotic regenerative nodule" should be avoided and replaced by "siderotic nodule".

Original languageEnglish (US)
Pages (from-to)773-776
Number of pages4
JournalJournal of Computer Assisted Tomography
Volume24
Issue number5
DOIs
StatePublished - 2000

Fingerprint

Magnetic Resonance Imaging
Iron
Liver Transplantation
Coloring Agents
Magnetic Resonance Spectroscopy

Keywords

  • Liver, cirrhosis
  • Liver, MR
  • Liver, neoplasm
  • Liver, nodules
  • Liver, transplantation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Krinsky, G. A., Lee, V. S., Nguyen, M. T., Rofsky, N. M., Theise, N. D., Morgan, G. R., ... Weinreb, J. C. (2000). Siderotic nodules at MR imaging: Regenerative or dysplastic? Journal of Computer Assisted Tomography, 24(5), 773-776. https://doi.org/10.1097/00004728-200009000-00019

Siderotic nodules at MR imaging : Regenerative or dysplastic? / Krinsky, Glenn A.; Lee, Vivian S.; Nguyen, Minh T.; Rofsky, Neil M.; Theise, Neil D.; Morgan, Glyn R.; Teperman, Lewis W.; Weinreb, Jeffrey C.

In: Journal of Computer Assisted Tomography, Vol. 24, No. 5, 2000, p. 773-776.

Research output: Contribution to journalArticle

Krinsky, GA, Lee, VS, Nguyen, MT, Rofsky, NM, Theise, ND, Morgan, GR, Teperman, LW & Weinreb, JC 2000, 'Siderotic nodules at MR imaging: Regenerative or dysplastic?', Journal of Computer Assisted Tomography, vol. 24, no. 5, pp. 773-776. https://doi.org/10.1097/00004728-200009000-00019
Krinsky, Glenn A. ; Lee, Vivian S. ; Nguyen, Minh T. ; Rofsky, Neil M. ; Theise, Neil D. ; Morgan, Glyn R. ; Teperman, Lewis W. ; Weinreb, Jeffrey C. / Siderotic nodules at MR imaging : Regenerative or dysplastic?. In: Journal of Computer Assisted Tomography. 2000 ; Vol. 24, No. 5. pp. 773-776.
@article{e744d906d7914cdc9e81833b5924cf47,
title = "Siderotic nodules at MR imaging: Regenerative or dysplastic?",
abstract = "Objective: To determine if iron containing {"}siderotic{"} nodules detected at magnetic resonance (MR) imaging are regenerative (RN) or dysplastic (DN) and to attempt to identify features that may distinguish them. Material and Methods: MR imaging (1.5 T) was performed on 77 cirrhotic patients who underwent orthotopic liver transplantation within 0-117 days (mean 30 days) of MR imaging. Two readers retrospectively evaluated breath-hold gradient-echo pulse sequences (echo time ≥9.0 ms, flip angle ≤45°) for the presence of hypointense nodules, which were classified as micronodular (≥3 mm), macronodular (>3 mm), or mixed. Nodule distribution was classified as focal (<5), scattered (5-20), or diffuse (>20) per slice. Thin section pathologic correlation was available in all cases, and Prussian blue iron stains were performed. Results: Of 35 patients with pathologically proven siderotic nodules, 10 (29{\%}) had at least 2 siderotic DN. MR detected siderotic nodules in 10 of 10 (100{\%}) patients with siderotic DN and RN, and in 18 of 25 patients (72{\%}) with siderotic RN only. Conclusion: Siderotic RN cannot be reliably distinguished from siderotic DN with MR imaging, and therefore the widely used term {"}siderotic regenerative nodule{"} should be avoided and replaced by {"}siderotic nodule{"}.",
keywords = "Liver, cirrhosis, Liver, MR, Liver, neoplasm, Liver, nodules, Liver, transplantation",
author = "Krinsky, {Glenn A.} and Lee, {Vivian S.} and Nguyen, {Minh T.} and Rofsky, {Neil M.} and Theise, {Neil D.} and Morgan, {Glyn R.} and Teperman, {Lewis W.} and Weinreb, {Jeffrey C.}",
year = "2000",
doi = "10.1097/00004728-200009000-00019",
language = "English (US)",
volume = "24",
pages = "773--776",
journal = "Journal of Computer Assisted Tomography",
issn = "0363-8715",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Siderotic nodules at MR imaging

T2 - Regenerative or dysplastic?

AU - Krinsky, Glenn A.

AU - Lee, Vivian S.

AU - Nguyen, Minh T.

AU - Rofsky, Neil M.

AU - Theise, Neil D.

AU - Morgan, Glyn R.

AU - Teperman, Lewis W.

AU - Weinreb, Jeffrey C.

PY - 2000

Y1 - 2000

N2 - Objective: To determine if iron containing "siderotic" nodules detected at magnetic resonance (MR) imaging are regenerative (RN) or dysplastic (DN) and to attempt to identify features that may distinguish them. Material and Methods: MR imaging (1.5 T) was performed on 77 cirrhotic patients who underwent orthotopic liver transplantation within 0-117 days (mean 30 days) of MR imaging. Two readers retrospectively evaluated breath-hold gradient-echo pulse sequences (echo time ≥9.0 ms, flip angle ≤45°) for the presence of hypointense nodules, which were classified as micronodular (≥3 mm), macronodular (>3 mm), or mixed. Nodule distribution was classified as focal (<5), scattered (5-20), or diffuse (>20) per slice. Thin section pathologic correlation was available in all cases, and Prussian blue iron stains were performed. Results: Of 35 patients with pathologically proven siderotic nodules, 10 (29%) had at least 2 siderotic DN. MR detected siderotic nodules in 10 of 10 (100%) patients with siderotic DN and RN, and in 18 of 25 patients (72%) with siderotic RN only. Conclusion: Siderotic RN cannot be reliably distinguished from siderotic DN with MR imaging, and therefore the widely used term "siderotic regenerative nodule" should be avoided and replaced by "siderotic nodule".

AB - Objective: To determine if iron containing "siderotic" nodules detected at magnetic resonance (MR) imaging are regenerative (RN) or dysplastic (DN) and to attempt to identify features that may distinguish them. Material and Methods: MR imaging (1.5 T) was performed on 77 cirrhotic patients who underwent orthotopic liver transplantation within 0-117 days (mean 30 days) of MR imaging. Two readers retrospectively evaluated breath-hold gradient-echo pulse sequences (echo time ≥9.0 ms, flip angle ≤45°) for the presence of hypointense nodules, which were classified as micronodular (≥3 mm), macronodular (>3 mm), or mixed. Nodule distribution was classified as focal (<5), scattered (5-20), or diffuse (>20) per slice. Thin section pathologic correlation was available in all cases, and Prussian blue iron stains were performed. Results: Of 35 patients with pathologically proven siderotic nodules, 10 (29%) had at least 2 siderotic DN. MR detected siderotic nodules in 10 of 10 (100%) patients with siderotic DN and RN, and in 18 of 25 patients (72%) with siderotic RN only. Conclusion: Siderotic RN cannot be reliably distinguished from siderotic DN with MR imaging, and therefore the widely used term "siderotic regenerative nodule" should be avoided and replaced by "siderotic nodule".

KW - Liver, cirrhosis

KW - Liver, MR

KW - Liver, neoplasm

KW - Liver, nodules

KW - Liver, transplantation

UR - http://www.scopus.com/inward/record.url?scp=0034466478&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034466478&partnerID=8YFLogxK

U2 - 10.1097/00004728-200009000-00019

DO - 10.1097/00004728-200009000-00019

M3 - Article

C2 - 11045701

AN - SCOPUS:0034466478

VL - 24

SP - 773

EP - 776

JO - Journal of Computer Assisted Tomography

JF - Journal of Computer Assisted Tomography

SN - 0363-8715

IS - 5

ER -