TY - JOUR
T1 - Signaling and transcriptional control of pancreatic organogenesis
AU - Kim, Seung K.
AU - MacDonald, Raymond J.
N1 - Funding Information:
The authors thank C Wright, M Hebrok and K Kaestner for permission to cite their work in press and G Swift, Å Apelqvist and I Rulifson for helpful comments on the manuscript. Research on this topic in the authors’ laboratories is supported by grants from the American Diabetes Association, and from the National Institutes of Health (SK Kim, DK56709; RJ MacDonald, DK55226).
PY - 2002/10/1
Y1 - 2002/10/1
N2 - The results of several new studies encourage a revision of fundamental hypotheses concerning the cellular and molecular mechanisms underlying pancreatic morphogenesis and cell differentiation in the embryo. The roles of FGF- and BMP-signaling indicate a fundamental difference in the induction of the dorsal and the ventral pancreatic anlage. Final commitment to the pancreatic fate requires the action of several transcriptional regulators including IPF1/PDX1, PBX1 and PTF1-P48 after the onset of pancreatic bud formation. Two, largely independent endocrine cell lineages develop during the formation of the embryonic pancreas. Lineage tracing has begun to refine our understanding of the origins of the acinar, ductal and islet cells.
AB - The results of several new studies encourage a revision of fundamental hypotheses concerning the cellular and molecular mechanisms underlying pancreatic morphogenesis and cell differentiation in the embryo. The roles of FGF- and BMP-signaling indicate a fundamental difference in the induction of the dorsal and the ventral pancreatic anlage. Final commitment to the pancreatic fate requires the action of several transcriptional regulators including IPF1/PDX1, PBX1 and PTF1-P48 after the onset of pancreatic bud formation. Two, largely independent endocrine cell lineages develop during the formation of the embryonic pancreas. Lineage tracing has begun to refine our understanding of the origins of the acinar, ductal and islet cells.
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U2 - 10.1016/S0959-437X(02)00338-6
DO - 10.1016/S0959-437X(02)00338-6
M3 - Review article
C2 - 12200159
AN - SCOPUS:0036777339
VL - 12
SP - 540
EP - 547
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
SN - 0959-437X
IS - 5
ER -