Signaling by Cellular Protrusions: Keeping the Conversation Private

Michael Buszczak, Mayu Inaba, Yukiko M. Yamashita

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Information exchange between different cells makes multicellular life possible. Signaling between cells can occur over long distances, as in the case of hormone signaling, or it can take place over short distances between immediately juxtaposed neighbors, as in the case of stem cell-niche signaling. The ability of signal-sending and -receiving cells to communicate with one another in a specific manner is of paramount importance in the proper development and function of tissues. Growing evidence indicates that different cellular protrusions help to achieve specificity in signaling that occurs between distinct cell types. Here, we focus on new roles for cellular protrusions in cell-to-cell communication, drawing special attention to how stem cells use specialized extensions to promote reception of self-renewing signals emanating from the niche. Cytonemes are specialized filopodia found in diverse tissues that promote signaling between specific cells over varying distances.Tunneling nanotubes (TNTs) share some structural similarities with cytonemes, and can traffic diverse cargos such as mitochondria, endosomal vesicles, viruses, and Ca2+.Microtubule-based nanotubes (MT nanotubes), formed by Drosophila germline stem cells, provide an exclusive surface area for productive signaling between niche cells and stem cells.

Original languageEnglish (US)
Pages (from-to)526-534
Number of pages9
JournalTrends in Cell Biology
Volume26
Issue number7
DOIs
StatePublished - Jul 1 2016

Keywords

  • Asymmetric stem cell division
  • Cytonemes
  • Nanotubes
  • Stem cell niche

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'Signaling by Cellular Protrusions: Keeping the Conversation Private'. Together they form a unique fingerprint.

Cite this