TY - JOUR
T1 - Signaling by Cellular Protrusions
T2 - Keeping the Conversation Private
AU - Buszczak, Michael
AU - Inaba, Mayu
AU - Yamashita, Yukiko M.
N1 - Funding Information:
We are grateful to the Buszczak and Yamashita lab members, Sunny Wong for helpful information, and Jose Cabrera for figure illustration. We apologize for not being able to cite all relevant studies owing to space limitation. The work in the Buszczak lab is supported by the National Institute on Aging (NIA; AG047318). The work in the Yamashita lab is supported by the Howard Hughes Medical Institute.
Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Information exchange between different cells makes multicellular life possible. Signaling between cells can occur over long distances, as in the case of hormone signaling, or it can take place over short distances between immediately juxtaposed neighbors, as in the case of stem cell-niche signaling. The ability of signal-sending and -receiving cells to communicate with one another in a specific manner is of paramount importance in the proper development and function of tissues. Growing evidence indicates that different cellular protrusions help to achieve specificity in signaling that occurs between distinct cell types. Here, we focus on new roles for cellular protrusions in cell-to-cell communication, drawing special attention to how stem cells use specialized extensions to promote reception of self-renewing signals emanating from the niche. Cytonemes are specialized filopodia found in diverse tissues that promote signaling between specific cells over varying distances.Tunneling nanotubes (TNTs) share some structural similarities with cytonemes, and can traffic diverse cargos such as mitochondria, endosomal vesicles, viruses, and Ca2+.Microtubule-based nanotubes (MT nanotubes), formed by Drosophila germline stem cells, provide an exclusive surface area for productive signaling between niche cells and stem cells.
AB - Information exchange between different cells makes multicellular life possible. Signaling between cells can occur over long distances, as in the case of hormone signaling, or it can take place over short distances between immediately juxtaposed neighbors, as in the case of stem cell-niche signaling. The ability of signal-sending and -receiving cells to communicate with one another in a specific manner is of paramount importance in the proper development and function of tissues. Growing evidence indicates that different cellular protrusions help to achieve specificity in signaling that occurs between distinct cell types. Here, we focus on new roles for cellular protrusions in cell-to-cell communication, drawing special attention to how stem cells use specialized extensions to promote reception of self-renewing signals emanating from the niche. Cytonemes are specialized filopodia found in diverse tissues that promote signaling between specific cells over varying distances.Tunneling nanotubes (TNTs) share some structural similarities with cytonemes, and can traffic diverse cargos such as mitochondria, endosomal vesicles, viruses, and Ca2+.Microtubule-based nanotubes (MT nanotubes), formed by Drosophila germline stem cells, provide an exclusive surface area for productive signaling between niche cells and stem cells.
KW - Asymmetric stem cell division
KW - Cytonemes
KW - Nanotubes
KW - Stem cell niche
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U2 - 10.1016/j.tcb.2016.03.003
DO - 10.1016/j.tcb.2016.03.003
M3 - Review article
C2 - 27032616
AN - SCOPUS:84974707518
SN - 0962-8924
VL - 26
SP - 526
EP - 534
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 7
ER -