TY - JOUR
T1 - Signaling chromatin to make muscle
AU - McKinsey, Timothy A.
AU - Zhang, Chun Li
AU - Olson, Eric N.
N1 - Funding Information:
We are grateful to A Tizenor for graphics and J Page for editorial assistance. Work in the authors' laboratory is supported by the National Institutes of Health, The Muscular Dystrophy Association, The Robert A Welch Foundation and The D.W. Reynolds Foundation for Clinical Cardiovascular Research. TAM was a Pfizer Fellow of The Life Sciences Research Foundation.
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Several findings published within the past year have further established key roles for chromatin-modifying enzymes in the control of muscle gene expression, and have thus refined our thinking of how chromatin structure influences muscle differentiation, hypertrophy and fiber type determination. We discuss the interface between chromatin-modifying enzymes and myogenic transcription factors, signaling mechanisms that impinge on these transcriptional complexes, and how these multicomponent regulatory cascades may be exploited in the development of novel therapeutics to more effectively treat myopathies in humans.
AB - Several findings published within the past year have further established key roles for chromatin-modifying enzymes in the control of muscle gene expression, and have thus refined our thinking of how chromatin structure influences muscle differentiation, hypertrophy and fiber type determination. We discuss the interface between chromatin-modifying enzymes and myogenic transcription factors, signaling mechanisms that impinge on these transcriptional complexes, and how these multicomponent regulatory cascades may be exploited in the development of novel therapeutics to more effectively treat myopathies in humans.
UR - http://www.scopus.com/inward/record.url?scp=1842843176&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1842843176&partnerID=8YFLogxK
U2 - 10.1016/S0955-0674(02)00389-7
DO - 10.1016/S0955-0674(02)00389-7
M3 - Review article
C2 - 12473352
AN - SCOPUS:1842843176
VL - 14
SP - 763
EP - 772
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
IS - 6
ER -