Signaling in malignant astrocytomas: Role of neural stem cells and its therapeutic implications

Sheila R. Alcantara Llaguno, Jian Chen, Luis F. Parada

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Malignant astrocytomas are infiltrative and aggressive brain tumors. Conventional forms of therapy have not been effective in controlling this incurable disease. Recent advances in understanding the molecular biology of these tumors have revealed potential mechanisms by which astrocytoma cells undergo tumor initiation, progression, and maintenance, as well as possible avenues for targeted therapeutics. Studies on the role of neural stem cells as cells of origin and tumor-propagating cells have also greatly increased our understanding of the biology and clinical behavior of these tumors. An integrated view of the genetics, signal transduction, and cell biology of astrocytomas, as well as clinical data from patients, will provide a more useful approach in designing novel therapies for this devastating disease.

Original languageEnglish (US)
Pages (from-to)7124-7129
Number of pages6
JournalClinical Cancer Research
Volume15
Issue number23
DOIs
StatePublished - Dec 1 2009

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Neural Stem Cells
Astrocytoma
Genetic Transduction
Neoplasms
Therapeutics
Brain Neoplasms
Cell Biology
Molecular Biology
Signal Transduction
Maintenance

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Signaling in malignant astrocytomas : Role of neural stem cells and its therapeutic implications. / Alcantara Llaguno, Sheila R.; Chen, Jian; Parada, Luis F.

In: Clinical Cancer Research, Vol. 15, No. 23, 01.12.2009, p. 7124-7129.

Research output: Contribution to journalArticle

Alcantara Llaguno, Sheila R. ; Chen, Jian ; Parada, Luis F. / Signaling in malignant astrocytomas : Role of neural stem cells and its therapeutic implications. In: Clinical Cancer Research. 2009 ; Vol. 15, No. 23. pp. 7124-7129.
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