Signaling networks in living cells

Michael A. White, Richard G W Anderson

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Recent advances in cell signaling research suggest that multiple sets of signal transducing molecules are preorganized and sequestered in distinct compartments within the cell. These compartments are assembled and maintained by specific cellular machinery. The molecular ecology within a compartment creates an environment that favors the efficient and accurate integration of signaling information arriving from humoral, mechanical, and nutritional sources. The functional organization of these compartments suggests they are the location of signaling networks that naturally organize into hierarchical interconnected sets of molecules through their participation in different classes of interacting units. An important goal is to determine the contribution of the compartment to the function of these networks in living cells.

Original languageEnglish (US)
Pages (from-to)587-603
Number of pages17
JournalAnnual Review of Pharmacology and Toxicology
Volume45
DOIs
StatePublished - Mar 2 2005

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Keywords

  • Caveolae
  • Compartmentalization
  • Scaffolding proteins
  • Signal transduction

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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