Abstract
Peyer's patches (PPs) and/or mesenteric lymph nodes (MLNs) are thought to be essential for immunoglobulin A (IgA) production. We found that the severe IgA deficiency in lymphotoxin-deficient (LT-/-) mice could be fully reversed by reconstitution with LT-expressing bone marrow, despite the absence of both LNs and PPs. The number of IgA precursors from LT-/- mice was not reduced, and they were able to migrate into the lamina propria (LP) of wild-type mice but not of LTβR-/- mice. Consistently, lymphoid tissue chemokines and adhesion molecules were reduced within the LP of LTα-/- and LTβR-/- mice. IgA deficiency in LTα-/- mice was reversed by the transplantation of a segment of RAG-1 (recombination-activating gene I)-deficient intestine, which confirmed the dispensability of the MLNs and PPs and the sufficiency of the LT-mediated gut microenvironment for IgA production.
Original language | English (US) |
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Pages (from-to) | 576-582 |
Number of pages | 7 |
Journal | Nature immunology |
Volume | 3 |
Issue number | 6 |
DOIs | |
State | Published - 2002 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology