Signaling via ltβr on the lamina propria stromal cells of the gut is required for iga production

Hyung Sik Kang, Robert K. Chin, Yang Wang, Ping Yu, Jun Wang, Kenneth A. Newell, Yang Xin Fu

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127 Scopus citations

Abstract

Peyer's patches (PPs) and/or mesenteric lymph nodes (MLNs) are thought to be essential for immunoglobulin A (IgA) production. We found that the severe IgA deficiency in lymphotoxin-deficient (LT-/-) mice could be fully reversed by reconstitution with LT-expressing bone marrow, despite the absence of both LNs and PPs. The number of IgA precursors from LT-/- mice was not reduced, and they were able to migrate into the lamina propria (LP) of wild-type mice but not of LTβR-/- mice. Consistently, lymphoid tissue chemokines and adhesion molecules were reduced within the LP of LTα-/- and LTβR-/- mice. IgA deficiency in LTα-/- mice was reversed by the transplantation of a segment of RAG-1 (recombination-activating gene I)-deficient intestine, which confirmed the dispensability of the MLNs and PPs and the sufficiency of the LT-mediated gut microenvironment for IgA production.

Original languageEnglish (US)
Pages (from-to)576-582
Number of pages7
JournalNature Immunology
Volume3
Issue number6
DOIs
StatePublished - Jan 1 2002

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ASJC Scopus subject areas

  • Immunology

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