TY - JOUR
T1 - Signatures of natural selection in the human genome
AU - Bamshad, Michael
AU - Wooding, Stephen P.
N1 - Funding Information:
We thank L. B. Jorde, A. R. Rogers and three anonymous reviewers for comments and criticisms. The authors are supported by funds from the US National Institutes of Health and the National Science Foundation.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - During their dispersal from Africa, our ancestors were exposed to new environments and diseases. Those who were better adapted to local conditions passed on their genes, including those conferring these benefits, with greater frequency. This process of natural selection left signatures in our genome that can be used to identify genes that might underlie variation in disease resistance or drug metabolism. These signatures are, however, confounded by population history and by variation in local recombination rates. Although this complexity makes finding adaptive polymorphisms a challenge, recent discoveries are instructing us how and where to look for the signatures of selection.
AB - During their dispersal from Africa, our ancestors were exposed to new environments and diseases. Those who were better adapted to local conditions passed on their genes, including those conferring these benefits, with greater frequency. This process of natural selection left signatures in our genome that can be used to identify genes that might underlie variation in disease resistance or drug metabolism. These signatures are, however, confounded by population history and by variation in local recombination rates. Although this complexity makes finding adaptive polymorphisms a challenge, recent discoveries are instructing us how and where to look for the signatures of selection.
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U2 - 10.1038/nrg999
DO - 10.1038/nrg999
M3 - Review article
C2 - 12560807
AN - SCOPUS:0037307413
SN - 1471-0056
VL - 4
SP - 99
EP - 111
JO - Nature reviews. Genetics
JF - Nature reviews. Genetics
IS - 2
ER -