Significance of rebounding parathyroid hormone levels during parathyroidectomy

David F. Schneider, Kristin A. Ojomo, Haggi Mazeh, Sarah C. Oltmann, Rebecca S. Sippel, Herbert Chen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Using minimally invasive parathyroidectomy (MIP), most surgeons require a 50% decline in intraoperative parathyroid hormone (IoPTH) to determine cure, but the significance of IoPTH kinetics occurring after this drop remains unknown. The aim of this study was to determine the impact of IoPTH levels that first meet criteria for cure, but then increase again, or rebound, between 10 and 15 min postexcision. Methods: We conducted a retrospective review of patients undergoing initial parathyroidectomy for primary hyperparathyroidism at our institution from 2001 to 2011. Rebound IoPTH was defined as an increase in parathyroid hormone ≥5 pg/mL after achieving the 50% drop required for cure. Comparisons were evaluated with the Student ttest, chi-square test, or Fisher exact test where appropriate. Results: Of the 1386 patients who met selection criteria, 86 (6.2%) patients exhibited rebound IoPTH. The mean magnitude of rebound was 13.8 ± 3.6 pg/mL. Compared with those not displaying rebound, more patients with rebound IoPTH were treated with open parathyroidectomy rather than MIP (10.8% versus 4.5%, P < 0.01). The recurrence rate among those with rebound IoPTH was more than double that of the patients without rebound IoPTH (5.8% versus 2.2%, P = 0.03). Magnitude of rebound, however, did not correlate with recurrence. The rate of persistent disease was not different between those with and without rebound IoPTH. Rebound was a much better indicator of recurrence than patients whose final IoPTH levels were not within the normal range. Conclusions: Rebound IoPTH is more common in patients who develop recurrent hyperparathyroidism. Therefore, surgeons should closely monitor patients with rebound IoPTH for disease recurrence.

Original languageEnglish (US)
Pages (from-to)265-268
Number of pages4
JournalJournal of Surgical Research
Volume184
Issue number1
DOIs
StatePublished - 2013

Fingerprint

Parathyroidectomy
Parathyroid Hormone
Recurrence
Parathyroid Diseases
Primary Hyperparathyroidism
Hyperparathyroidism
Chi-Square Distribution
Patient Selection
Reference Values

Keywords

  • Intraoperative parathyroid hormone monitoring
  • Minimally invasive parathyroidectomy
  • Primary hyperparathyroidism
  • Recurrence

ASJC Scopus subject areas

  • Surgery

Cite this

Significance of rebounding parathyroid hormone levels during parathyroidectomy. / Schneider, David F.; Ojomo, Kristin A.; Mazeh, Haggi; Oltmann, Sarah C.; Sippel, Rebecca S.; Chen, Herbert.

In: Journal of Surgical Research, Vol. 184, No. 1, 2013, p. 265-268.

Research output: Contribution to journalArticle

Schneider, David F. ; Ojomo, Kristin A. ; Mazeh, Haggi ; Oltmann, Sarah C. ; Sippel, Rebecca S. ; Chen, Herbert. / Significance of rebounding parathyroid hormone levels during parathyroidectomy. In: Journal of Surgical Research. 2013 ; Vol. 184, No. 1. pp. 265-268.
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abstract = "Background: Using minimally invasive parathyroidectomy (MIP), most surgeons require a 50{\%} decline in intraoperative parathyroid hormone (IoPTH) to determine cure, but the significance of IoPTH kinetics occurring after this drop remains unknown. The aim of this study was to determine the impact of IoPTH levels that first meet criteria for cure, but then increase again, or rebound, between 10 and 15 min postexcision. Methods: We conducted a retrospective review of patients undergoing initial parathyroidectomy for primary hyperparathyroidism at our institution from 2001 to 2011. Rebound IoPTH was defined as an increase in parathyroid hormone ≥5 pg/mL after achieving the 50{\%} drop required for cure. Comparisons were evaluated with the Student ttest, chi-square test, or Fisher exact test where appropriate. Results: Of the 1386 patients who met selection criteria, 86 (6.2{\%}) patients exhibited rebound IoPTH. The mean magnitude of rebound was 13.8 ± 3.6 pg/mL. Compared with those not displaying rebound, more patients with rebound IoPTH were treated with open parathyroidectomy rather than MIP (10.8{\%} versus 4.5{\%}, P < 0.01). The recurrence rate among those with rebound IoPTH was more than double that of the patients without rebound IoPTH (5.8{\%} versus 2.2{\%}, P = 0.03). Magnitude of rebound, however, did not correlate with recurrence. The rate of persistent disease was not different between those with and without rebound IoPTH. Rebound was a much better indicator of recurrence than patients whose final IoPTH levels were not within the normal range. Conclusions: Rebound IoPTH is more common in patients who develop recurrent hyperparathyroidism. Therefore, surgeons should closely monitor patients with rebound IoPTH for disease recurrence.",
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