Significantly increased PELP1 protein expression in primary and metastatic triple-negative breast carcinoma: Comparison with GATA3 expression and PELP1's potential role in triple-negative breast carcinoma

Daniel N. Dang, Ganesh Raj, Venetia Sarode, Kyle H. Molberg, Ratna K. Vadlamudi, Yan Peng

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

PELP1 is a novel coregulator of nuclear hormone receptors and is implicated in playing a role in driving breast cancer and enhancing metastatic potential. The PELP1 protein expression and potential role of PELP1 in triple-negative breast carcinoma (TNBC) have not been well characterized. We investigated PELP1 expression by immunohistochemistry in primary and metastatic triple-negative tumors in human tissues and compared its expression with GATA-binding protein 3 (GATA3), a novel diagnostic marker for TNBC. We examined the expression of PELP1 and GATA3 in 70 primary TNBC cases and found that PELP1 had a significantly higher frequency of expression compared to GATA3 (96% versus 46%; P

Original languageEnglish (US)
Pages (from-to)1829-1835
Number of pages7
JournalHuman Pathology
Volume46
Issue number12
DOIs
StatePublished - Dec 1 2015

Keywords

  • GATA3
  • Immunohistochemistry
  • Metastasis
  • PELP1
  • Triple-negative breast carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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