The relationship between cyclo-oxygenase-2 -1195A/G gene polymorphism and renal cell carcinoma

Objective: This study was aimed to evaluate the association of cyclo-oxygenase 2 (COX-2) -1195A/G polymorphism with initiation and progression of renal cell carcinoma (RCC) and interaction with smoking in RCC patients in a Turkish population. Methods: The COX-2 -1195A/G gene polymorphism was analyzed by method of polymerase chain reaction in DNA samples of 154 healthy controls and 114 patients with RCC. Results: No significant variation in terms of age, sex, body mass index (BMI) or smoking between RCC patients and controls was observed. There was no statistical significance between COX-2 -1195A/G gene polymorphism and onset or progression of RCC in patients and controls (p>0.05). In addition, no relationship was identified regarding high stage and poorly differentiated RCC risk after adjusting for age, sex, BMI and smoking status. Furthermore, this polymorphism was not significantly associated with development of RCC when accompanied by smoking status. Conclusion: Our results showed that the COX-2 -1195A/G polymorphism does not seem to be a major risk factor for both the onset and progression of RCC in a Turkish population.