Abstract
Cell division cycle 42 (CDC42), a small GTPase of the Rho-subfamily, regulates diverse cellular functions including proliferation, cytoskeletal rearrangement and even promotes malignant transformation. Here, we found that increased expression of CDC42 correlated with undifferentiated neuroblastoma as compared to a more benign phenotype. CDC42 inhibition decreased cell growth and soft agar colony formation, and increased cell death in BE(2)-C and BE(2)-M17 cell lines, but not in SK-N-AS. In addition, silencing of CDC42 decreased expression of N-myc in BE(2)-C and BE(2)-M17 cells. Our findings suggest that CDC42 may play a role in the regulation of aggressive neuroblastoma behavior.
Original language | English (US) |
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Pages (from-to) | 210-216 |
Number of pages | 7 |
Journal | Cancer Letters |
Volume | 355 |
Issue number | 2 |
DOIs | |
State | Published - Dec 28 2014 |
Externally published | Yes |
Keywords
- AKT2
- CDC42
- N-myc
- Neuroblastoma
- Transformation
- Twist
ASJC Scopus subject areas
- Oncology
- Cancer Research