Silencing of CDC42 inhibits neuroblastoma cell proliferation and transformation

Sora Lee, Brian T. Craig, Carmelle V. Romain, Jingbo Qiao, Dai H. Chung

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Cell division cycle 42 (CDC42), a small GTPase of the Rho-subfamily, regulates diverse cellular functions including proliferation, cytoskeletal rearrangement and even promotes malignant transformation. Here, we found that increased expression of CDC42 correlated with undifferentiated neuroblastoma as compared to a more benign phenotype. CDC42 inhibition decreased cell growth and soft agar colony formation, and increased cell death in BE(2)-C and BE(2)-M17 cell lines, but not in SK-N-AS. In addition, silencing of CDC42 decreased expression of N-myc in BE(2)-C and BE(2)-M17 cells. Our findings suggest that CDC42 may play a role in the regulation of aggressive neuroblastoma behavior.

Original languageEnglish (US)
Pages (from-to)210-216
Number of pages7
JournalCancer Letters
Volume355
Issue number2
DOIs
StatePublished - Dec 28 2014
Externally publishedYes

Keywords

  • AKT2
  • CDC42
  • N-myc
  • Neuroblastoma
  • Transformation
  • Twist

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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