Silicon multi-nanochannel FETs to improve device uniformity/stability and femtomolar detection of insulin in serum

Suresh Regonda, Ruhai Tian, Jinming Gao, Serena Greene, Jiahuan Ding, Walter Hu

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Here we demonstrate the use of multiple Si nanochannel (NC) or nanograting (NG) instead of the conventional single nanochannel or nanowire design in biosensors. The NG devices can significantly reduce device-to-device variation, and improve device performance, e.g. higher current, higher ON/OFF ratio, smaller subthreshold slope, lower threshold voltage Vt in buffer solution. NG devices also result in higher sensor stability in buffer and diluted human serum. We believe such improvements are due to reduced discrete dopant fluctuation in the Si nanowires and biochemical noise in the solution because of the multiple-channel design. The improved devices allow us to sense pH linearly with 3-aminopropyltriethoxysilane coated devices, and to selectively detect insulin with limit of detection down to 10fM in both buffer solution and diluted human serum without pre-purification.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalBiosensors and Bioelectronics
Volume45
Issue number1
DOIs
StatePublished - Jul 5 2013

Fingerprint

Insulin
Silicon
Field effect transistors
Buffers
Equipment and Supplies
Nanowires
Serum
Threshold voltage
Biosensors
Purification
Doping (additives)
Sensors
Biosensing Techniques
Noise
Limit of Detection

Keywords

  • Bio-FETs
  • Biosensor
  • Diabetes
  • Insulin
  • Nanowire
  • PH sensing
  • Si nanograting

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Biotechnology
  • Electrochemistry

Cite this

Silicon multi-nanochannel FETs to improve device uniformity/stability and femtomolar detection of insulin in serum. / Regonda, Suresh; Tian, Ruhai; Gao, Jinming; Greene, Serena; Ding, Jiahuan; Hu, Walter.

In: Biosensors and Bioelectronics, Vol. 45, No. 1, 05.07.2013, p. 245-251.

Research output: Contribution to journalArticle

Regonda, Suresh ; Tian, Ruhai ; Gao, Jinming ; Greene, Serena ; Ding, Jiahuan ; Hu, Walter. / Silicon multi-nanochannel FETs to improve device uniformity/stability and femtomolar detection of insulin in serum. In: Biosensors and Bioelectronics. 2013 ; Vol. 45, No. 1. pp. 245-251.
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