Similar T-cell oligoclonality in antimitochondrial antibody-positive and -negative primary biliary cirrhosis

M. J. Mayo, P. E. Lipsky, S. N. Miller, P. Stastny, B. Combes

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Approximately 5% of patients with clinical and histological features suggestive of primary biliary cirrhosis do not have anti-mitochondrial antibodies that can be detected by current methodologies. Although the role of these autoantibodies in the pathogenesis of liver disease is uncertain, T lymphocytes within the portal tracts are felt to be important mediators of bile duct destruction. In order to investigate the hypothesis that a similar T-cell process may be involved in both antimitochondrial antibody-positive and -negative primary biliary cirrhosis, we characterized the oligoclonally expanded T cells in both types of patients by analysis of complementarity determining region 3 length in peripheral blood mononuclear cells. The distribution of oligoclonally expanded T cells was similar in both groups. This finding does not support a distinct T-cell-mediated pathogenesis for anti-mitochondrial antibody-positive and -negative primary biliary cirrhosis but rather suggests that similar processes may be involved in the immunopathogenesis of both.

Original languageEnglish (US)
Pages (from-to)345-351
Number of pages7
JournalDigestive Diseases and Sciences
Volume46
Issue number2
DOIs
StatePublished - 2001

Keywords

  • Autoimmunity
  • Cholangiopathy
  • Cholangitis
  • Liver

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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