Similarities and controversies in imaging of pediatric renal tumors: A SIOP-RTSG and COG collaboration

Justine N. van der Beek, Maddy Artunduaga, Jens Peter Schenk, Meryle J. Eklund, Ethan A. Smith, Henrique M. Lederman, Anne B. Warwick, Annemieke S. Littooij, Geetika Khanna

Research output: Contribution to journalReview articlepeer-review


Malignant renal tumors are rare in children, and Wilms tumors (WTs) are the most common subtype. Imaging plays an essential role in the diagnosis, staging, and follow-up of these patients. Initial workup for staging is mainly performed by cross-sectional imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI). Imaging approach within the two core international groups, the Children's Oncology Group (COG, North America) and the International Society of Pediatric Oncology - Renal Tumor Study Group (SIOP-RTSG, Europe), differs. Whereas abdominal ultrasound (US) is used for the initial diagnosis of a suspected pediatric renal tumor globally, COG protocols support the use of CT or MRI for locoregional staging, contrary to the preference for MRI over CT for abdominopelvic evaluation within the SIOP-RTSG. The purpose of this manuscript is to summarize current imaging approaches, highlighting differences and similarities within these core international groups, while focusing on future innovative efforts and collaboration within the HARMONICA initiative.

Original languageEnglish (US)
JournalPediatric Blood and Cancer
StateAccepted/In press - 2022
Externally publishedYes


  • computed tomography
  • kidney neoplasms
  • magnetic resonance imaging
  • pediatrics
  • radiology
  • ultrasonography

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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