Simple bone cysts: The effects of methylprednisolone on synovial cells in culture

C. Yu, J. D'Astous, M. Finnegan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Ten years ago, a protocol using Depo-Medrol injections was developed for the treatment of unicameral bone cysts. This concept, designed by tumor surgeons and based on theory, has been cautiously approached. However, reproducible results have gradually increased clinical acceptance. Understanding the healing process has been restricted because of the lack of an experimental model. In an attempt to elucidate this mechanism of healing, a cell culture model was used to investigate the effects of methylprednisolone on synovial cells. Initially, three doses of the drug were tested and maximal changes were noted with the concentration of 40 mg/ml. Changes were then quantified by morphology, DNA assay, cell protein analysis, and electron microscopy. Results suggest that methylprednisolone may have a direct effect on the cellular component of unicameral bone cysts.

Original languageEnglish (US)
Pages (from-to)34-41
Number of pages8
JournalClinical Orthopaedics and Related Research
Issue number262
StatePublished - 1991

Fingerprint

Bone Cysts
Methylprednisolone
Cell Culture Techniques
Electron Microscopy
Theoretical Models
Injections
DNA
Pharmaceutical Preparations
Neoplasms
Proteins
Therapeutics
methylprednisolone acetate
Surgeons

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Simple bone cysts : The effects of methylprednisolone on synovial cells in culture. / Yu, C.; D'Astous, J.; Finnegan, M.

In: Clinical Orthopaedics and Related Research, No. 262, 1991, p. 34-41.

Research output: Contribution to journalArticle

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