Abstract
3,3-Disubstituted cyclopropenes have been readily prepared in a multigram scale via two different methods: (1) dehydrohalogenation of bromocyclopropanes, and (2) Rh-catalyzed addition of carbenoids to trimethylsilylacetylene followed by desilylation. Highly diastereoselective Pd-catalyzed hydrostannation and highly enantioselective Rh-catalyzed hydroboration of 3,3-disubstituted cyclopropenes afforded useful cyclopropylmetal building blocks in high yields.
Original language | English (US) |
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Pages (from-to) | 796-800 |
Number of pages | 5 |
Journal | Synthesis |
Issue number | 5 |
State | Published - Apr 2 2004 |
Externally published | Yes |
Keywords
- Cyclopropane
- Cyclopropene
- Hydroboration
- Hydrostannation
- Transition metal catalysis
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry