Simultaneous contrast ultrasound and DCE MRI for improved breast tumour characterization: demonstration of technical feasibility

Rajiv Chopra, David Goertz, Laura Curiel, Kullervo Hynynen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) shows promise for characterizing breast tumours and monitoring their response to therapies. Unfortunately, it suffers from the limitation that the measured signal arises from both within and outside blood vessels, and the images cannot be acquired fast enough to accurately characterize tumours. Contrast ultrasound signals arise only from blood and can be acquired with high temporal resolution, addressing two major weaknesses of DCE-MRL The technical feasibility of combining contrast ultrasound imaging with DCE-MRI for simultaneous measurements of contrast agent dynamics was explored in this study. Pulse-inversion B-scan ultrasound imaging was performed in a closed-bore clinical MR imager using a non-magnetic linear positioning system, and by placing the pre-amps and isolation circuits at the bore of the magnet. Initial experiments in a rabbit kidney model demonstrate the feasibility of performing simultaneous contrast imaging with both modalities.

Original languageEnglish (US)
Title of host publication2007 IEEE Ultrasonics Symposium Proceedings, IUS
Pages644-647
Number of pages4
DOIs
StatePublished - Dec 1 2007
Event2007 IEEE Ultrasonics Symposium, IUS - New York, NY, United States
Duration: Oct 28 2007Oct 31 2007

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117

Other

Other2007 IEEE Ultrasonics Symposium, IUS
CountryUnited States
CityNew York, NY
Period10/28/0710/31/07

Keywords

  • Contrast agents
  • MRI
  • Multi-modality
  • Simultaneous imaging
  • Ultrasound

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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    Chopra, R., Goertz, D., Curiel, L., & Hynynen, K. (2007). Simultaneous contrast ultrasound and DCE MRI for improved breast tumour characterization: demonstration of technical feasibility. In 2007 IEEE Ultrasonics Symposium Proceedings, IUS (pp. 644-647). [4409740] (Proceedings - IEEE Ultrasonics Symposium). https://doi.org/10.1109/ULTSYM.2007.167