TY - GEN
T1 - Simultaneous Evalulation of Contrast Pulse Sequences for Super-Resolution Ultrasound Imaging - Preliminary in Vitro and in Vivo Results
AU - Brown, Katherine
AU - Hoyt, Kenneth
PY - 2020/7
Y1 - 2020/7
N2 - Super-resolution ultrasound imaging (SR-US) has enabled a tenfold improvement in resolution of the microvasculature with clinical application in many disease processes such as cancer, diabetes and cardiovascular disease. Plane wave ultrasound (US) platforms in turn are capable of the very high frame rates needed to track microbubble (MB) contrast agents used in SR-US. Both B-mode US imaging and contrast enhanced US imaging (CEUS) have been effectively used in SR-US, with B-mode US having higher signal-to-noise ratio (SNR) and CEUS providing higher contrast-to-tissue ratio (CTR). Lengthy imaging time needed for SR-US to allow perfusion and MB detection is an impediment to clinical adoption. Both SNR and CTR improvements can enhance SR-US imaging by enhancing the detection of MBs thus reducing imaging time. This study simultaneously evaluated nonlinear contrast pulse sequences (CPS) employing different amplitude modulation (AM) and pulse inversion (PI) nonlinear CEUS imaging techniques as well as combinations of the two, (AMPI) with B-mode US imaging. The objective was to improve the detection rate of MB during SR-US. Imaging was performed in vitro and in vivo in the rat hind limb using a Vantage 256 research scanner (Verasonics Inc.). Comparisons of four CPS compositions with B-mode US imaging was made based on the number of MB detected and localized in SR-US images. The use of a PI nonlinear CEUS imaging strategy improved SR-US imaging by increasing the number of MB detected in a sequence of frames by an average of 28.3% and up to 52.6% over a B-mode US imaging strategy, which would decrease imaging time accordingly.
AB - Super-resolution ultrasound imaging (SR-US) has enabled a tenfold improvement in resolution of the microvasculature with clinical application in many disease processes such as cancer, diabetes and cardiovascular disease. Plane wave ultrasound (US) platforms in turn are capable of the very high frame rates needed to track microbubble (MB) contrast agents used in SR-US. Both B-mode US imaging and contrast enhanced US imaging (CEUS) have been effectively used in SR-US, with B-mode US having higher signal-to-noise ratio (SNR) and CEUS providing higher contrast-to-tissue ratio (CTR). Lengthy imaging time needed for SR-US to allow perfusion and MB detection is an impediment to clinical adoption. Both SNR and CTR improvements can enhance SR-US imaging by enhancing the detection of MBs thus reducing imaging time. This study simultaneously evaluated nonlinear contrast pulse sequences (CPS) employing different amplitude modulation (AM) and pulse inversion (PI) nonlinear CEUS imaging techniques as well as combinations of the two, (AMPI) with B-mode US imaging. The objective was to improve the detection rate of MB during SR-US. Imaging was performed in vitro and in vivo in the rat hind limb using a Vantage 256 research scanner (Verasonics Inc.). Comparisons of four CPS compositions with B-mode US imaging was made based on the number of MB detected and localized in SR-US images. The use of a PI nonlinear CEUS imaging strategy improved SR-US imaging by increasing the number of MB detected in a sequence of frames by an average of 28.3% and up to 52.6% over a B-mode US imaging strategy, which would decrease imaging time accordingly.
UR - http://www.scopus.com/inward/record.url?scp=85091005549&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85091005549&partnerID=8YFLogxK
U2 - 10.1109/EMBC44109.2020.9176087
DO - 10.1109/EMBC44109.2020.9176087
M3 - Conference contribution
C2 - 33018425
AN - SCOPUS:85091005549
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 2121
EP - 2124
BT - 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020
Y2 - 20 July 2020 through 24 July 2020
ER -