Simultaneous irrigation and negative pressure wound therapy enhances wound healing and reduces wound bioburden in a porcine model

Kathryn Davis, Jessica Bills, Jenny Barker, Paul Kim, Lawrence Lavery

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Infected foot wounds are one of the most common reasons for hospitalization and amputation among persons with diabetes. The objective of the study was to investigate a new wound therapy system that employs negative pressure wound therapy (NPWT) with simultaneous irrigation therapy. For this study, we used a porcine model with full-thickness excisional wounds, inoculated with Pseudomonas aeruginosa. Wounds were treated for 21 days of therapy with either NPWT, NPWT with simultaneous irrigation therapy using normal saline or polyhexanide biguanide (PHMB) at low or high flow rates, or control. Data show that NPWT with either irrigation condition improved wound healing rates over control-treated wounds, yet did not differ from NPWT alone. NPWT improved bioburden over control-treated wounds. NPWT with simultaneous irrigation further reduced bioburden over control and NPWT-treated wounds; however, flow rate did not affect these outcomes. Together, these data show that NPWT with simultaneous irrigation therapy with either normal saline or PHMB has a positive effect on bioburden in a porcine model, which may translate clinically to improved wound healing outcomes.

Original languageEnglish (US)
Pages (from-to)869-875
Number of pages7
JournalWound Repair and Regeneration
Volume21
Issue number6
DOIs
StatePublished - Nov 1 2013

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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