Simultaneous measurement of macro- and microvascular blood flow and oxygen saturation for quantification of muscle oxygen consumption

Erin K. Englund, Zachary B. Rodgers, Michael C. Langham, Emile R. Mohler, Thomas F. Floyd, Felix W. Wehrli

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: To investigate the relationship between blood flow and oxygen consumption in skeletal muscle, a technique called "Velocity and Perfusion, Intravascular Venous Oxygen saturation and T2*" (vPIVOT) is presented. vPIVOT allows the quantification of feeding artery blood flow velocity, perfusion, draining vein oxygen saturation, and muscle T2*, all at 4-s temporal resolution. Together, the measurement of blood flow and oxygen extraction can yield muscle oxygen consumption ( V˙O2) via the Fick principle. Methods: In five subjects, vPIVOT-derived results were compared with those obtained from stand-alone sequences during separate ischemia-reperfusion paradigms to investigate the presence of measurement bias. Subsequently, in 10 subjects, vPIVOT was applied to assess muscle hemodynamics and V˙O2 following a bout of dynamic plantar flexion contractions. Results: From the ischemia-reperfusion paradigm, no significant differences were observed between data from vPIVOT and comparison sequences. After exercise, the macrovascular flow response reached a maximum 8±3 s after relaxation; however, perfusion in the gastrocnemius muscle continued to rise for 101±53 s. Peak V˙O2 calculated based on mass-normalized arterial blood flow or perfusion was 15.2±6.7mL O2/min/100g or 6.0±1.9mL O2/min/100g, respectively. Conclusions: vPIVOT is a new method to measure blood flow and oxygen saturation, and therefore to quantify muscle oxygen consumption.

Original languageEnglish (US)
JournalMagnetic Resonance in Medicine
DOIs
StateAccepted/In press - Jan 1 2017

Fingerprint

Oxygen Consumption
Perfusion
Oxygen
Muscles
Reperfusion
Skeletal Muscle
Ischemia
Blood Flow Velocity
Veins
Arteries
Hemodynamics

Keywords

  • Exercise
  • Ischemia
  • Muscle
  • Oxygen consumption
  • Perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Simultaneous measurement of macro- and microvascular blood flow and oxygen saturation for quantification of muscle oxygen consumption. / Englund, Erin K.; Rodgers, Zachary B.; Langham, Michael C.; Mohler, Emile R.; Floyd, Thomas F.; Wehrli, Felix W.

In: Magnetic Resonance in Medicine, 01.01.2017.

Research output: Contribution to journalArticle

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