Simultaneous pancreas and kidney transplantation for liver transplant recipients with diabetes and uremia

Ngalei Tam, Chuanzhao Zhang, Jianwei Lin, Chenglin Wu, Ronghai Deng, Bing Liao, Shuiqing Hu, Dongping Wang, Xiaofeng Zhu, Linwei Wu, Xiaoshun He

Research output: Contribution to journalArticle

Abstract

Background and objectives: Chronic kidney disease (CKD) has become a critical problem due to immunosuppressant related nephrotoxicity in liver transplant (LTx) recipients, especially in patients with pre-transplant risk factors. LTx recipients with uraemia and diabetes have poor prognosis even when treated with dialysis and insulin. Simultaneous pancreas and kidney transplantation (SPK) has been proven to be an effective treatment for patients with diabetic uraemia, but rarely performed in patients after LTx. Two cases of SPK after LTx were performed in our centre and we present our experience here. Patients and methods: Two patients received LTx because of HBV related liver cirrhosis; both of them had pre-transplant diabetes mellitus (DM), which worsened after the administration of immunosuppressive drugs. These two patients suffered from CKD and developed uraemia due to diabetic nephropathy and immunosuppressive drugs induced renal toxicity years after LTx. They relied on dialysis and insulin injection. SPK were performed years after LTx and the clinical data was retrospectively analyzed. Results: SPK was successfully performed in these two patients. Pancreatic fluid drainage was achieved via a side-to-side duodenojejunostomy into the proximal jejunum. No serious surgical complications, including pancreatitis or pancreatic fistula were observed postoperatively. In both cases, kidney and pancreatic grafts were functioning well as evidenced by euglycemia without the need for insulin injections and normal serum-creatinine level 7. days after the operation. One of the patients presented with renal graft impairment 1. week after the operation. FK506 was tapered and rapamycin was used when the renal graft biopsy indicated drug toxicity. The patient's kidney graft function recovered gradually after the adjustment. Both patients have good function of liver, kidney and pancreas grafts during a 60-month and 30-month period of follow up. Conclusions: SPK could serve as an effective option for patients with diabetes and uremia after LTx. Perioperative management, especially the immunosuppressive strategy is crucial to improve the outcome of this procedure.

Original languageEnglish (US)
Pages (from-to)399-404
Number of pages6
JournalClinics and Research in Hepatology and Gastroenterology
Volume39
Issue number3
DOIs
StatePublished - Jan 1 2015

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Pancreas Transplantation
Uremia
Kidney Transplantation
Liver
Transplants
Immunosuppressive Agents
Kidney
Insulin
Chronic Renal Insufficiency
Dialysis
Transplant Recipients
Pancreatic Fistula
Injections
Diabetic Nephropathies
Tacrolimus
Sirolimus
Jejunum
Drug-Related Side Effects and Adverse Reactions
Liver Cirrhosis
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Gastroenterology

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Simultaneous pancreas and kidney transplantation for liver transplant recipients with diabetes and uremia. / Tam, Ngalei; Zhang, Chuanzhao; Lin, Jianwei; Wu, Chenglin; Deng, Ronghai; Liao, Bing; Hu, Shuiqing; Wang, Dongping; Zhu, Xiaofeng; Wu, Linwei; He, Xiaoshun.

In: Clinics and Research in Hepatology and Gastroenterology, Vol. 39, No. 3, 01.01.2015, p. 399-404.

Research output: Contribution to journalArticle

Tam, Ngalei ; Zhang, Chuanzhao ; Lin, Jianwei ; Wu, Chenglin ; Deng, Ronghai ; Liao, Bing ; Hu, Shuiqing ; Wang, Dongping ; Zhu, Xiaofeng ; Wu, Linwei ; He, Xiaoshun. / Simultaneous pancreas and kidney transplantation for liver transplant recipients with diabetes and uremia. In: Clinics and Research in Hepatology and Gastroenterology. 2015 ; Vol. 39, No. 3. pp. 399-404.
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AU - Tam, Ngalei

AU - Zhang, Chuanzhao

AU - Lin, Jianwei

AU - Wu, Chenglin

AU - Deng, Ronghai

AU - Liao, Bing

AU - Hu, Shuiqing

AU - Wang, Dongping

AU - Zhu, Xiaofeng

AU - Wu, Linwei

AU - He, Xiaoshun

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