The transcription factor FOXP1 is one of the top five genes associated with autism spectrum disorder and has conserved enriched expression in striatal spiny projection neurons (SPNs). Anderson et al. show at single-cell resolution that Foxp1 is critical for proper striatal development and functions within distinct striatal cell types in mice.
- single-cell RNA sequencing
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)