Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development

Ashley G. Anderson, Ashwinikumar Kulkarni, Matthew Harper, Genevieve Konopka

Research output: Contribution to journalArticle

Abstract

The transcription factor FOXP1 is one of the top five genes associated with autism spectrum disorder and has conserved enriched expression in striatal spiny projection neurons (SPNs). Anderson et al. show at single-cell resolution that Foxp1 is critical for proper striatal development and functions within distinct striatal cell types in mice.

Original languageEnglish (US)
Pages (from-to)3051-3066.e7
JournalCell Reports
Volume30
Issue number9
DOIs
StatePublished - Mar 3 2020

Keywords

  • autism
  • FOXP1
  • neurodevelopment
  • single-cell RNA sequencing
  • striatum

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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