Single-dose administration of a short-acting gonadotropin-releasing hormone agonist does not affect cycle outcome in frozen–thawed embryo transfer cycles

Hanbi Wang, Xian Tang, Orhan Bukulmez, Chengyan Deng, Qi Yu, Yuanzheng Zhou, Zhengyi Sun, Jingran Zhen, Xue Wang, Meizhi Liu

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: This prospective study aimed to assess the effect of short-acting gonadotropin-releasing hormone agonist (GnRHa) administration on pregnancy outcomes in frozen–thawed embryo transfer (FET) cycles. Methods: Patients who planned to have FET in Peking Union Medical College Hospital (China) were recruited for this study and randomly assigned into two groups. Patients in the experimental group (n = 460) received triptorelin acetate on the day of embryo transfer along with routine luteal support. Patients in the control group (n = 433) only received luteal support. One dose (0.1 mg) of a short-acting GnRHa was administered on the day of blastocyte transfer. The rates for clinical pregnancy, biochemical pregnancy, implantation, miscarriage, and ectopic pregnancy were compared between the groups. Results: There were no significant differences in the number and quality of blastocytes transferred between the two groups. In the experimental and control groups, the clinical pregnancy rate was 56.3% and 50.58%, the biochemical pregnancy rate was 15.78% and 18.94%, and the median implantation rate was 39.98% and 38.01%, respectively, with no significant difference between the groups. Biochemical pregnancy and abortion and the ectopic pregnancy rate were not significantly different between the two groups. Conclusion: In FET cycles, a GnRHa does not affect the pregnancy outcome.

Original languageEnglish (US)
JournalJournal of International Medical Research
Volume49
Issue number5
DOIs
StatePublished - 2021

Keywords

  • abortion
  • blastocyte
  • frozen–thawed cycle
  • Gonadotropin-releasing hormone agonist
  • in vitro fertilization–embryo transfer
  • pregnancy

ASJC Scopus subject areas

  • Biochemistry
  • Biochemistry, medical
  • Cell Biology

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