Single-dose antimicrobial prophylaxis at abdominal hysterectomy: Cefamandole vs. cefotaxime

D. L. Hemsell, J. N. Martin, J. G. Pastorek, B. J. Nobles, P. G. Hemsell, N. Helman, P. Blake, M. K. Lindsey, S. K. Nicaud

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Two hundred twenty-three women were given a single, 1-g, intravenous dose of cefamandole or cefotaxime at elective abdominal hysterectomy in a multicenter, prospective, randomized, blind clinical trial of efficacy and safety. The demographic, surgical, efficacy and safety variables were statistically similar. Prior to discharge from the hospital, 12 women (5.3%) developed major postoperative pelvic infections that required parenteral antimicrobial therapy; no wound infections occurred. There was no correlation between a depressed antimicrobial concentration in serum and/or tissue and the development of significant postoperative infection. An expanded spectrum of antibacterial activity and a longer serum half-life did not improve clinical efficacy, and single-dose intravenous cephalosporin prophylaxis before abdominal hysterectomy was associated with a low incidence of pelvic infection.

Original languageEnglish (US)
Pages (from-to)939-944
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume33
Issue number12
StatePublished - 1988

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Pelvic Infection
Cefamandole
Cefotaxime
Hysterectomy
Safety
Wound Infection
Cephalosporins
Serum
Half-Life
Randomized Controlled Trials
Demography
Incidence
Infection
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Hemsell, D. L., Martin, J. N., Pastorek, J. G., Nobles, B. J., Hemsell, P. G., Helman, N., ... Nicaud, S. K. (1988). Single-dose antimicrobial prophylaxis at abdominal hysterectomy: Cefamandole vs. cefotaxime. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 33(12), 939-944.

Single-dose antimicrobial prophylaxis at abdominal hysterectomy : Cefamandole vs. cefotaxime. / Hemsell, D. L.; Martin, J. N.; Pastorek, J. G.; Nobles, B. J.; Hemsell, P. G.; Helman, N.; Blake, P.; Lindsey, M. K.; Nicaud, S. K.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 33, No. 12, 1988, p. 939-944.

Research output: Contribution to journalArticle

Hemsell, DL, Martin, JN, Pastorek, JG, Nobles, BJ, Hemsell, PG, Helman, N, Blake, P, Lindsey, MK & Nicaud, SK 1988, 'Single-dose antimicrobial prophylaxis at abdominal hysterectomy: Cefamandole vs. cefotaxime', Journal of Reproductive Medicine for the Obstetrician and Gynecologist, vol. 33, no. 12, pp. 939-944.
Hemsell, D. L. ; Martin, J. N. ; Pastorek, J. G. ; Nobles, B. J. ; Hemsell, P. G. ; Helman, N. ; Blake, P. ; Lindsey, M. K. ; Nicaud, S. K. / Single-dose antimicrobial prophylaxis at abdominal hysterectomy : Cefamandole vs. cefotaxime. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 1988 ; Vol. 33, No. 12. pp. 939-944.
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