Single-dose cefamandole and cefotaxime prophylaxis at vaginal and abdominal hysterectomy

D. L. Hemsell, P. G. Hemsell, B. J. Nobles, M. C. Heard

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Two hundred forty-one women were randomly given 1 g of either cefamandole or cefotaxime intravenously in the operating room prior to vaginal or abdominal hysterectomy in a prospective, blinded clinical trial of antimicrobial prophylaxis. Eight of 163 women (4.9%) developed operative site infection requiring parenteral antimicrobial therapy after abdominal hysterectomy, as did 2 of 78 women (2.6%) after vaginal hysterectomy, without significant interregimen differences. Five of 8 (62.5%) infections that developed after abdominal hysterectomy followed patients' discharge from the hospital. There were many significant interprocedure, but not interregimen, differences in demographic, surgical, and outcome variables - confirming benefits for women when vaginal hysterectomy is possible.

Original languageEnglish (US)
Pages (from-to)97-102
Number of pages6
JournalAdvances in Therapy
Volume5
Issue number4
StatePublished - 1988

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Cefamandole
Vaginal Hysterectomy
Cefotaxime
Hysterectomy
Patient Discharge
Operating Rooms
Infection
Demography
Clinical Trials

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Single-dose cefamandole and cefotaxime prophylaxis at vaginal and abdominal hysterectomy. / Hemsell, D. L.; Hemsell, P. G.; Nobles, B. J.; Heard, M. C.

In: Advances in Therapy, Vol. 5, No. 4, 1988, p. 97-102.

Research output: Contribution to journalArticle

Hemsell, D. L. ; Hemsell, P. G. ; Nobles, B. J. ; Heard, M. C. / Single-dose cefamandole and cefotaxime prophylaxis at vaginal and abdominal hysterectomy. In: Advances in Therapy. 1988 ; Vol. 5, No. 4. pp. 97-102.
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