Single-dose prophylaxis for vaginal and abdominal hysterectomy.

D. L. Hemsell, M. C. Heard, B. J. Nobles, R. E. Bawdon, P. G. Hemsell

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The practice of administering perioperative antimicrobials to uninfected patients undergoing elective surgical procedures has been subjected to careful prospective investigative scrutiny during the past two decades. A wound classification system was developed, helping to identify procedures for which prophylaxis did not provide benefit to the patient. Guidelines for prophylaxis in hysterectomy were proposed and risk factors were sought. Pharmacokinetics and spectrum of antibacterial activity, although variables of paramount importance in predicting success in the treatment of established infections, were discovered to have questionable impact on prophylactic efficacy. Duration of antimicrobial administration has gradually diminished from the total length of hospital stay to a single preoperative dose without increased risk of infection; efficacy may be related to route of administration. The wisdom of using newer agents for prophylaxis is addressed and questioned.

Original languageEnglish (US)
Pages (from-to)498-501
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume157
Issue number2
StatePublished - Aug 1987

Fingerprint

Vaginal Hysterectomy
Length of Stay
Elective Surgical Procedures
Infection
Hysterectomy
Pharmacokinetics
Guidelines
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Hemsell, D. L., Heard, M. C., Nobles, B. J., Bawdon, R. E., & Hemsell, P. G. (1987). Single-dose prophylaxis for vaginal and abdominal hysterectomy. American Journal of Obstetrics and Gynecology, 157(2), 498-501.

Single-dose prophylaxis for vaginal and abdominal hysterectomy. / Hemsell, D. L.; Heard, M. C.; Nobles, B. J.; Bawdon, R. E.; Hemsell, P. G.

In: American Journal of Obstetrics and Gynecology, Vol. 157, No. 2, 08.1987, p. 498-501.

Research output: Contribution to journalArticle

Hemsell, DL, Heard, MC, Nobles, BJ, Bawdon, RE & Hemsell, PG 1987, 'Single-dose prophylaxis for vaginal and abdominal hysterectomy.', American Journal of Obstetrics and Gynecology, vol. 157, no. 2, pp. 498-501.
Hemsell, D. L. ; Heard, M. C. ; Nobles, B. J. ; Bawdon, R. E. ; Hemsell, P. G. / Single-dose prophylaxis for vaginal and abdominal hysterectomy. In: American Journal of Obstetrics and Gynecology. 1987 ; Vol. 157, No. 2. pp. 498-501.
@article{e280a8b90c194b2da47d019f9b83b242,
title = "Single-dose prophylaxis for vaginal and abdominal hysterectomy.",
abstract = "The practice of administering perioperative antimicrobials to uninfected patients undergoing elective surgical procedures has been subjected to careful prospective investigative scrutiny during the past two decades. A wound classification system was developed, helping to identify procedures for which prophylaxis did not provide benefit to the patient. Guidelines for prophylaxis in hysterectomy were proposed and risk factors were sought. Pharmacokinetics and spectrum of antibacterial activity, although variables of paramount importance in predicting success in the treatment of established infections, were discovered to have questionable impact on prophylactic efficacy. Duration of antimicrobial administration has gradually diminished from the total length of hospital stay to a single preoperative dose without increased risk of infection; efficacy may be related to route of administration. The wisdom of using newer agents for prophylaxis is addressed and questioned.",
author = "Hemsell, {D. L.} and Heard, {M. C.} and Nobles, {B. J.} and Bawdon, {R. E.} and Hemsell, {P. G.}",
year = "1987",
month = "8",
language = "English (US)",
volume = "157",
pages = "498--501",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Single-dose prophylaxis for vaginal and abdominal hysterectomy.

AU - Hemsell, D. L.

AU - Heard, M. C.

AU - Nobles, B. J.

AU - Bawdon, R. E.

AU - Hemsell, P. G.

PY - 1987/8

Y1 - 1987/8

N2 - The practice of administering perioperative antimicrobials to uninfected patients undergoing elective surgical procedures has been subjected to careful prospective investigative scrutiny during the past two decades. A wound classification system was developed, helping to identify procedures for which prophylaxis did not provide benefit to the patient. Guidelines for prophylaxis in hysterectomy were proposed and risk factors were sought. Pharmacokinetics and spectrum of antibacterial activity, although variables of paramount importance in predicting success in the treatment of established infections, were discovered to have questionable impact on prophylactic efficacy. Duration of antimicrobial administration has gradually diminished from the total length of hospital stay to a single preoperative dose without increased risk of infection; efficacy may be related to route of administration. The wisdom of using newer agents for prophylaxis is addressed and questioned.

AB - The practice of administering perioperative antimicrobials to uninfected patients undergoing elective surgical procedures has been subjected to careful prospective investigative scrutiny during the past two decades. A wound classification system was developed, helping to identify procedures for which prophylaxis did not provide benefit to the patient. Guidelines for prophylaxis in hysterectomy were proposed and risk factors were sought. Pharmacokinetics and spectrum of antibacterial activity, although variables of paramount importance in predicting success in the treatment of established infections, were discovered to have questionable impact on prophylactic efficacy. Duration of antimicrobial administration has gradually diminished from the total length of hospital stay to a single preoperative dose without increased risk of infection; efficacy may be related to route of administration. The wisdom of using newer agents for prophylaxis is addressed and questioned.

UR - http://www.scopus.com/inward/record.url?scp=0023392858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023392858&partnerID=8YFLogxK

M3 - Article

VL - 157

SP - 498

EP - 501

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 2

ER -