Single-dose prophylaxis in patients undergoing vaginal hysterectomy: Cefamandole versus cefotaxime

J. C. Morrison, J. N. Martin, P. G. Blake, P. R. Howard, D. L. Hemsell, P. G. Hemsell, B. J. Nobles, M. L. Heard, A. J. Fenton, R. M. Bernstein, A. S. Berkeley, K. S. Freedman, R. H. Brakemeier, C. V. Capen, A. G. McHaffey, C. Fouts-Johnson, E. P. King

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The efficacy of perioperative antimicrobial prophylaxis in preventing infection after vaginal hysterectomy has been demonstrated. In this study 260 patients undergoing vaginal hysterectomy were randomly assigned at five centers to receive 1 gm of cefamandole (N = 129) or cefotaxime (N = 131) immediately before operation. The two treatment groups were comparable. Febrile morbidity occurred in seven (5.4%) cefamandole patients and in 17 (13%) of those given cefotaxime (p = 0.04). In contrast, the number of patients who developed major pelvic infection was equal (cefamandole, 6; cefotaxime, 5). There was no significant difference in the concentration of either drug in the serum or tissues surveyed, and there was no correlation between infection and concentration of antibiotic in either group. The mean hospital stay and the mean total hospitalization charge did not differ significantly between the two groups. Both of these agents given as a single dose before vaginal hysterectomy are effective in reducing postoperative infections.

Original languageEnglish (US)
Pages (from-to)1198-1201
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume160
Issue number5 I
StatePublished - 1989

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Single-dose prophylaxis in patients undergoing vaginal hysterectomy: Cefamandole versus cefotaxime'. Together they form a unique fingerprint.

  • Cite this

    Morrison, J. C., Martin, J. N., Blake, P. G., Howard, P. R., Hemsell, D. L., Hemsell, P. G., Nobles, B. J., Heard, M. L., Fenton, A. J., Bernstein, R. M., Berkeley, A. S., Freedman, K. S., Brakemeier, R. H., Capen, C. V., McHaffey, A. G., Fouts-Johnson, C., & King, E. P. (1989). Single-dose prophylaxis in patients undergoing vaginal hysterectomy: Cefamandole versus cefotaxime. American Journal of Obstetrics and Gynecology, 160(5 I), 1198-1201.