Single Institutional experience with observing 564 vestibular schwannomas: Factors associated with tumor growth

Jacob B. Hunter, David O. Francis, Brendan P. O'Connell, Edmond K. Kabagambe, Marc L. Bennett, George B. Wanna, Alejandro Rivas, Reid C. Thompson, David S. Haynes

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To characterize the risk and predictors of growth during observation of vestibular schwannomas (VS). Study Design: Retrospective case series. Setting: Single academic, tertiary care center. Patients: Five hundred sixty-four consecutive VS patients who underwent at least two magnetic resonance imaging (MRI) studies before intervention. Intervention(s): Serial MRI studies. Main Outcome Measure(s): Tumor growth, defined as a 2mm increase in the maximum tumor diameter between consecutive MRI studies, or between the first and last study. Results: A total of 1296 patients (1995-2015) with VS were identified. Of those, 564 patients (median age 59.2 years; 53.5% female) were initially observed and underwent multiple MRI studies (median follow-up 22.9 months, interquartile range [IQR] 11.7-42.7). The median maximum tumor diameter at presentation was 1.00 cm (IQR 0.6- 1.51 cm). In all, 40.8% of tumors demonstrated growth and 32.1% underwent intervention (21.5% microsurgery, 10.5% radiation) during the surveillance period. Multivariable Cox regression analysis showed that for each tumor, the risk of growth or intervention was significantly increased for larger initial VS diameters (HR=2.22; 95% CI: 1.90-2.61) and when disequilibrium was a presenting symptom (HR=1.70; 95% CI: 1.30-2.23). Patient age, sex, aspirin use, and presenting symptoms of asymmetric hearing loss, tinnitus, and vertigo were not associated with tumor growth. Conclusion: To date, this is the largest series of observed VS reported in the literature. Risk of VS growth is significantly increased among patients who present with larger tumors and who have concomitant disequilibrium. IRB: 151481. Define Professional Practice Gap and Educational Need: No cohort with this sample size has assessed vestibular schwannoma growth rates in conjunction with this number of variables. Learning Objective: To characterize vestibular schwannoma growth rates and predictors of growth.

Original languageEnglish (US)
Pages (from-to)1630-1636
Number of pages7
JournalOtology and Neurotology
Volume37
Issue number10
DOIs
StatePublished - Nov 28 2016

Fingerprint

Acoustic Neuroma
Growth
Neoplasms
Magnetic Resonance Imaging
Microsurgery
Tinnitus
Research Ethics Committees
Vertigo
Hearing Loss
Tertiary Care Centers
Sample Size
Aspirin
Retrospective Studies
Regression Analysis
Observation
Outcome Assessment (Health Care)
Learning
Radiation

Keywords

  • Acoustic neuroma
  • Natural history
  • Observation
  • Skull base
  • Vertigo
  • Vestibular schwannoma

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Sensory Systems
  • Clinical Neurology

Cite this

Hunter, J. B., Francis, D. O., O'Connell, B. P., Kabagambe, E. K., Bennett, M. L., Wanna, G. B., ... Haynes, D. S. (2016). Single Institutional experience with observing 564 vestibular schwannomas: Factors associated with tumor growth. Otology and Neurotology, 37(10), 1630-1636. https://doi.org/10.1097/MAO.0000000000001219

Single Institutional experience with observing 564 vestibular schwannomas : Factors associated with tumor growth. / Hunter, Jacob B.; Francis, David O.; O'Connell, Brendan P.; Kabagambe, Edmond K.; Bennett, Marc L.; Wanna, George B.; Rivas, Alejandro; Thompson, Reid C.; Haynes, David S.

In: Otology and Neurotology, Vol. 37, No. 10, 28.11.2016, p. 1630-1636.

Research output: Contribution to journalArticle

Hunter, JB, Francis, DO, O'Connell, BP, Kabagambe, EK, Bennett, ML, Wanna, GB, Rivas, A, Thompson, RC & Haynes, DS 2016, 'Single Institutional experience with observing 564 vestibular schwannomas: Factors associated with tumor growth', Otology and Neurotology, vol. 37, no. 10, pp. 1630-1636. https://doi.org/10.1097/MAO.0000000000001219
Hunter, Jacob B. ; Francis, David O. ; O'Connell, Brendan P. ; Kabagambe, Edmond K. ; Bennett, Marc L. ; Wanna, George B. ; Rivas, Alejandro ; Thompson, Reid C. ; Haynes, David S. / Single Institutional experience with observing 564 vestibular schwannomas : Factors associated with tumor growth. In: Otology and Neurotology. 2016 ; Vol. 37, No. 10. pp. 1630-1636.
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AU - Bennett, Marc L.

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AU - Rivas, Alejandro

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N2 - Objective: To characterize the risk and predictors of growth during observation of vestibular schwannomas (VS). Study Design: Retrospective case series. Setting: Single academic, tertiary care center. Patients: Five hundred sixty-four consecutive VS patients who underwent at least two magnetic resonance imaging (MRI) studies before intervention. Intervention(s): Serial MRI studies. Main Outcome Measure(s): Tumor growth, defined as a 2mm increase in the maximum tumor diameter between consecutive MRI studies, or between the first and last study. Results: A total of 1296 patients (1995-2015) with VS were identified. Of those, 564 patients (median age 59.2 years; 53.5% female) were initially observed and underwent multiple MRI studies (median follow-up 22.9 months, interquartile range [IQR] 11.7-42.7). The median maximum tumor diameter at presentation was 1.00 cm (IQR 0.6- 1.51 cm). In all, 40.8% of tumors demonstrated growth and 32.1% underwent intervention (21.5% microsurgery, 10.5% radiation) during the surveillance period. Multivariable Cox regression analysis showed that for each tumor, the risk of growth or intervention was significantly increased for larger initial VS diameters (HR=2.22; 95% CI: 1.90-2.61) and when disequilibrium was a presenting symptom (HR=1.70; 95% CI: 1.30-2.23). Patient age, sex, aspirin use, and presenting symptoms of asymmetric hearing loss, tinnitus, and vertigo were not associated with tumor growth. Conclusion: To date, this is the largest series of observed VS reported in the literature. Risk of VS growth is significantly increased among patients who present with larger tumors and who have concomitant disequilibrium. IRB: 151481. Define Professional Practice Gap and Educational Need: No cohort with this sample size has assessed vestibular schwannoma growth rates in conjunction with this number of variables. Learning Objective: To characterize vestibular schwannoma growth rates and predictors of growth.

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