Single-photon emission computed tomography in neurotherapeutics

Michael D. Devous

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The measurement of regional cerebral blood flow (rCBF) by single-photon emission computed tomography (SPECT) is a powerful clinical and research tool. There are several clinical applications now documented, a substantial number under active investigation, and a larger number yet to be studied. Standards regarding patient imaging environment and image presentation are becoming established. This article reviews key aspects of SPECT functional brain imaging in clinical practice, with a particular emphasis on therapeutics, including 1) the quality of the tomographic device, 2) the radiopharmaceutical employed, 3) environmental conditions at the time of radiotracer administration, 4) characteristics of the subject, 5) the format used for image presentation, and 6) the essential components of image processing necessary to the achievement of high-quality SPECT brain images. Next, a brief description of relevant radiation safety issues is provided. Finally, applications in molecular imaging, especially in small animal imaging for research as well as drug discovery and development are discussed. The gamut of SPECT studies from currently routine clinical applications to molecular imaging offers a wonderful frontier for opportunities to employ functional brain imaging in neurotherapeutics.

Original languageEnglish (US)
Pages (from-to)237-249
Number of pages13
JournalNeuroRx
Volume2
Issue number2
DOIs
StatePublished - Apr 2005

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Single-Photon Emission-Computed Tomography
Functional Neuroimaging
Molecular Imaging
Cerebrovascular Circulation
Radiopharmaceuticals
Regional Blood Flow
Drug Discovery
Radiation
Safety
Equipment and Supplies
Brain
Research
Therapeutics

Keywords

  • Instrumentation
  • Molecular imaging
  • Radiopharmaceuticals
  • rCBF
  • SPECT

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Single-photon emission computed tomography in neurotherapeutics. / Devous, Michael D.

In: NeuroRx, Vol. 2, No. 2, 04.2005, p. 237-249.

Research output: Contribution to journalArticle

Devous, Michael D. / Single-photon emission computed tomography in neurotherapeutics. In: NeuroRx. 2005 ; Vol. 2, No. 2. pp. 237-249.
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