Single synapse evaluation of the postsynaptic NMDA receptors targeted by evoked and spontaneous neurotransmission

Austin L. Reese, Ege T. Kavalali

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Recent studies indicate that within individual synapses spontaneous and evoked release processes are segregated and regulated independently. In the hippocampus, earlier electrophysiological recordings suggested that spontaneous and evoked glutamate release can activate separate groups of postsynaptic NMDA receptors with limited overlap. However, it is still unclear how this separation of NMDA receptors is distributed across individual synapses. In a previous paper (Reese and Kavalali, 2015) we showed that NMDA receptor mediated spontaneous transmission signals to the postsynaptic protein translation machinery through Ca2+- induced Ca2+ release. Here, we show that in rat hippocampal neurons although spontaneous and evoked glutamate release driven NMDA receptor mediated Ca2+ transients often occur at the same synapse, these two signals do not show significant correlation or cross talk.

Original languageEnglish (US)
Article numbere21170
JournaleLife
Volume5
Issue numberNOVEMBER2016
DOIs
StatePublished - Nov 24 2016

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N-Methyl-D-Aspartate Receptors
Synaptic Transmission
Synapses
Glutamic Acid
Protein Biosynthesis
Neurons
Machinery
Rats
Hippocampus
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Single synapse evaluation of the postsynaptic NMDA receptors targeted by evoked and spontaneous neurotransmission. / Reese, Austin L.; Kavalali, Ege T.

In: eLife, Vol. 5, No. NOVEMBER2016, e21170, 24.11.2016.

Research output: Contribution to journalArticle

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