Abstract
Recent studies indicate that within individual synapses spontaneous and evoked release processes are segregated and regulated independently. In the hippocampus, earlier electrophysiological recordings suggested that spontaneous and evoked glutamate release can activate separate groups of postsynaptic NMDA receptors with limited overlap. However, it is still unclear how this separation of NMDA receptors is distributed across individual synapses. In a previous paper (Reese and Kavalali, 2015) we showed that NMDA receptor mediated spontaneous transmission signals to the postsynaptic protein translation machinery through Ca2+- induced Ca2+ release. Here, we show that in rat hippocampal neurons although spontaneous and evoked glutamate release driven NMDA receptor mediated Ca2+ transients often occur at the same synapse, these two signals do not show significant correlation or cross talk.
| Original language | English (US) |
|---|---|
| Article number | e21170 |
| Journal | eLife |
| Volume | 5 |
| Issue number | NOVEMBER2016 |
| DOIs | |
| State | Published - Nov 24 2016 |
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ASJC Scopus subject areas
- Neuroscience(all)
- Medicine(all)
- Immunology and Microbiology(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Single synapse evaluation of the postsynaptic NMDA receptors targeted by evoked and spontaneous neurotransmission. / Reese, Austin L.; Kavalali, Ege T.
In: eLife, Vol. 5, No. NOVEMBER2016, e21170, 24.11.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Single synapse evaluation of the postsynaptic NMDA receptors targeted by evoked and spontaneous neurotransmission
AU - Reese, Austin L.
AU - Kavalali, Ege T.
PY - 2016/11/24
Y1 - 2016/11/24
N2 - Recent studies indicate that within individual synapses spontaneous and evoked release processes are segregated and regulated independently. In the hippocampus, earlier electrophysiological recordings suggested that spontaneous and evoked glutamate release can activate separate groups of postsynaptic NMDA receptors with limited overlap. However, it is still unclear how this separation of NMDA receptors is distributed across individual synapses. In a previous paper (Reese and Kavalali, 2015) we showed that NMDA receptor mediated spontaneous transmission signals to the postsynaptic protein translation machinery through Ca2+- induced Ca2+ release. Here, we show that in rat hippocampal neurons although spontaneous and evoked glutamate release driven NMDA receptor mediated Ca2+ transients often occur at the same synapse, these two signals do not show significant correlation or cross talk.
AB - Recent studies indicate that within individual synapses spontaneous and evoked release processes are segregated and regulated independently. In the hippocampus, earlier electrophysiological recordings suggested that spontaneous and evoked glutamate release can activate separate groups of postsynaptic NMDA receptors with limited overlap. However, it is still unclear how this separation of NMDA receptors is distributed across individual synapses. In a previous paper (Reese and Kavalali, 2015) we showed that NMDA receptor mediated spontaneous transmission signals to the postsynaptic protein translation machinery through Ca2+- induced Ca2+ release. Here, we show that in rat hippocampal neurons although spontaneous and evoked glutamate release driven NMDA receptor mediated Ca2+ transients often occur at the same synapse, these two signals do not show significant correlation or cross talk.
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UR - http://www.scopus.com/inward/citedby.url?scp=85005991818&partnerID=8YFLogxK
U2 - 10.7554/eLife.21170
DO - 10.7554/eLife.21170
M3 - Article
C2 - 27882871
AN - SCOPUS:85005991818
VL - 5
JO - eLife
JF - eLife
SN - 2050-084X
IS - NOVEMBER2016
M1 - e21170
ER -