Single-voided urine metanephrine assays in screening for pheochromocytoma

Norman M Kaplan; N. J. Kramer; O. B. Holland; S. G. Sheps; C. Gomez-Sanchez

doi:10.1001/archinte.137.2.190

Single-voided urine metanephrine assays in screening for pheochromocytoma

Norman M Kaplan, N. J. Kramer, O. B. Holland, S. G. Sheps, C. Gomez-Sanchez

Research output: Contribution to journal › Article › peer-review

Abstract

To facilitate the screening for pheochromocytoma, the authors have validated the use of single-voided, spot urine specimens for the determination of total metanephrines. Metanephrine excretion was found to be quite constant throughout the day and night in ten patients with essential hypertension and seven patients with pheochromocytoma. The levels in single-voided specimens were closely correlated to those in 24-hour specimens in 100 hypertensive subjects. The mean ± 2 SD metanephrine excretion in single-voided urine specimens from 500 hypertensive subjects was 0.351 ± 0.356 μg/mg of creatinine.

Original language	English (US)
Pages (from-to)	190-193
Number of pages	4
Journal	Archives of Internal Medicine
Volume	137
Issue number	2
DOIs	https://doi.org/10.1001/archinte.137.2.190
State	Published - 1977

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Internal Medicine

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10.1001/archinte.137.2.190

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AU - Gomez-Sanchez, C.

PY - 1977

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AB - To facilitate the screening for pheochromocytoma, the authors have validated the use of single-voided, spot urine specimens for the determination of total metanephrines. Metanephrine excretion was found to be quite constant throughout the day and night in ten patients with essential hypertension and seven patients with pheochromocytoma. The levels in single-voided specimens were closely correlated to those in 24-hour specimens in 100 hypertensive subjects. The mean ± 2 SD metanephrine excretion in single-voided urine specimens from 500 hypertensive subjects was 0.351 ± 0.356 μg/mg of creatinine.

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Single-voided urine metanephrine assays in screening for pheochromocytoma

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