Single-Voided Urine Metanephrine Assays in Screening for Pheochromocytoma

Norman M Kaplan, Norman J. Kramer, O. Bryan Holland, Sheldon G. Sheps, Celso Gomez Sanchez

Research output: Contribution to journalArticle

34 Scopus citations


To facilitate the screening for pheochromocytoma, we have validated the use of single-voided, spot urine specimens for the determination of total metanephrines. Metanephrine excretion was found to be quite constant throughout the day and night in ten patients with essential hypertension and seven patients with pheochromocytoma. The levels in single-voided specimens were closely correlated to those in 24-hour specimens in 100 hypertensive subjects. The mean ± 2 SD metanephrine excretion in single-voided urine specimens from 500 hypertensive subjects was 0.351 ± 0.356 μg/mg of creatinine.

Original languageEnglish (US)
Pages (from-to)190-193
Number of pages4
JournalArchives of Internal Medicine
Issue number2
StatePublished - 1977

ASJC Scopus subject areas

  • Internal Medicine

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    Kaplan, N. M., Kramer, N. J., Holland, O. B., Sheps, S. G., & Gomez Sanchez, C. (1977). Single-Voided Urine Metanephrine Assays in Screening for Pheochromocytoma. Archives of Internal Medicine, 137(2), 190-193.