siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P₃-mTOR signaling pathway as a primary regulator of transferrin uptake

Agriculture & Biology

• small interfering RNA 79%
• transferrin 77%
• proteome 66%
• uptake mechanisms 45%
• transferrin receptors 40%
• endocytosis 30%
• iron 30%
• target of rapamycin signaling pathways 22%
• phosphatidylinositol 3-kinase 17%
• phosphatidylinositols 14%
• transport proteins 14%
• RNA interference 14%
• recycling 12%
• neoplasm cells 12%
• cell growth 11%
• image analysis 11%
• lymphocytes 11%
• viability 10%
• screening 9%
• cells 8%
• proteins 4%

Medicine & Life Sciences

• phosphatidylinositol 3,4,5-triphosphate 100%
• Transferrin 73%
• Proteome 71%
• Small Interfering RNA 57%
• Iron 34%
• Transferrin Receptors 33%
• Endocytosis 27%
• Transport Vesicles 17%
• Recycling 15%
• Sirolimus 14%
• Phosphatidylinositol 3-Kinases 13%
• RNA Interference 13%
• Carrier Proteins 11%
• Cell Survival 10%
• Lymphocytes 9%
• Cell Proliferation 9%
• Growth 6%
• Proteins 5%
• Neoplasms 4%

Earth & Environmental Sciences

• cell 18%
• RNA 15%
• iron 15%
• protein 10%
• tumor 7%
• vesicle 7%
• viability 7%
• screening 6%
• recycling 5%
• rate 4%