Sixteen years and counting: An update on leptin in energy balance

Research output: Contribution to journalArticle

240 Citations (Scopus)

Abstract

Cloned in 1994, the ob gene encodes the protein hormone leptin, which is produced and secreted by white adipose tissue. Since its discovery, leptin has been found to have profound effects on behavior, metabolic rate, endocrine axes, and glucose fluxes. Leptin deficiency in mice and humans causes morbid obesity, diabetes, and various neuroendocrine anomalies, and replacement leads to decreased food intake, normalized glucose homeostasis, and increased energy expenditure. Here, we provide an update on the most current understanding of leptin-sensitive neural pathways in terms of both anatomical organization and physiological roles.

Original languageEnglish (US)
Pages (from-to)2087-2093
Number of pages7
JournalJournal of Clinical Investigation
Volume121
Issue number6
DOIs
StatePublished - Jun 1 2011

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Leptin
Glucose
Neural Pathways
White Adipose Tissue
Morbid Obesity
Energy Metabolism
Homeostasis
Eating
Hormones
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sixteen years and counting : An update on leptin in energy balance. / Gautron, Laurent; Elmquist, Joel K.

In: Journal of Clinical Investigation, Vol. 121, No. 6, 01.06.2011, p. 2087-2093.

Research output: Contribution to journalArticle

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