TY - JOUR
T1 - Sixteen years and counting
T2 - An update on leptin in energy balance
AU - Gautron, Laurent
AU - Elmquist, Joel K.
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Cloned in 1994, the ob gene encodes the protein hormone leptin, which is produced and secreted by white adipose tissue. Since its discovery, leptin has been found to have profound effects on behavior, metabolic rate, endocrine axes, and glucose fluxes. Leptin deficiency in mice and humans causes morbid obesity, diabetes, and various neuroendocrine anomalies, and replacement leads to decreased food intake, normalized glucose homeostasis, and increased energy expenditure. Here, we provide an update on the most current understanding of leptin-sensitive neural pathways in terms of both anatomical organization and physiological roles.
AB - Cloned in 1994, the ob gene encodes the protein hormone leptin, which is produced and secreted by white adipose tissue. Since its discovery, leptin has been found to have profound effects on behavior, metabolic rate, endocrine axes, and glucose fluxes. Leptin deficiency in mice and humans causes morbid obesity, diabetes, and various neuroendocrine anomalies, and replacement leads to decreased food intake, normalized glucose homeostasis, and increased energy expenditure. Here, we provide an update on the most current understanding of leptin-sensitive neural pathways in terms of both anatomical organization and physiological roles.
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U2 - 10.1172/JCI45888
DO - 10.1172/JCI45888
M3 - Review article
C2 - 21633176
AN - SCOPUS:79957896666
SN - 0021-9738
VL - 121
SP - 2087
EP - 2093
JO - Journal of Clinical Investigation
JF - Journal of Clinical Investigation
IS - 6
ER -