Skeletal Metastasis Evaluation: Value and Impact of PET/Computed Tomography on Diagnosis, Management and Prognosis

Stephen M. Broski, Jason R. Young, Ayse T. Kendi, Rathan Subramaniam

Research output: Contribution to journalReview article

4 Scopus citations


A number of PET agents are useful for evaluation of skeletal metastatic disease, and have significant advantages over 99mTc-MDP scintigraphy, including superior diagnostic accuracy, higher spatial resolution, and shorter imaging times- often with the ability to depict soft tissue local recurrence and metastasis in the same examination. While these agents have excellent diagnostic utility, they are not 100% specific for skeletal metastasis, and so normal patterns of biodistribution, benign osseous lesions that may demonstrate radiotracer uptake, and the significance of morphologic changes on CT such as osteolysis or osteosclerosis must be kept in mind to ensure accurate interpretation.

Original languageEnglish (US)
Pages (from-to)103-120
Number of pages18
JournalPET Clinics
Issue number1
Publication statusPublished - Jan 1 2019



  • Choline
  • FDG
  • Fluciclovine
  • NaF
  • PET/CT
  • Skeletal metastasis

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging

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