Skeletal muscle injury after magnesium depletion in the dog

R. E. Cronin, E. R. Ferguson, W. A. Shannon, J. P. Knochel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Magnesium deficiency was induced in a setting of an otherwise adequate diet in adult beagle dogs. Despite the development of severe hypomagnesemia (from 1.5 ± 0.2 to 0.5 ± 0.2 meq/liter) during the 10-wk study, Mg content of skeletal muscle fell only modestly (from 3.8 ± 0.2 to 3.1 ± 0.4, P < 0.005, at 7 wk and 3.5 ± 0.4 mM/100 g FFDS, NS, at 10 wk). The most pronounced muscle compositional changes were a loss of phosphorus (from 29.5 ± 1.8 to 22.0 ± 1.6, P < 0.001, at 7 wk and 24.8 ± 2.8 mM/100 g FFDS, P < 0.001, at 10 wk) and gains of calcium (from 0.64 ± 0.11 to 0.93 ± 0.17, P < 0.05, at 7 wk, and 0.85 ± 0.26 mM/100 g FFDS, P < 0.05, at 10 wk), sodium (from 13.2 ± 2.6 to 22.9 ± 4.7, P < 0.001 at 7 wk and 17.8 ± 2.0 meq/100 g FFDS, P < 0.005, at 10 wk), and chloride (from 5.8 ± 0.8 to 8.2 ± 1.6, P < 0.001, at 7 wk and 6.8 ± 0.6 meq/100 g FFDS, P < 0.05, at 10 wk). Cellular potassium content did not change (from 35.9 ± 1.9 to 33.0 ± 4.1, NS, at 7 wk and 36.3 ± 2.0 meq/100 g FFDS, NS, at 10 wk). Muscle cell electrical hyperpolarization developed after 10 wk of Mg depletion. Convulsive seizures developed in three animals. Frank rhabdomyolysis in three animals and focal necrosis in four animals were present on terminal biopsy, with only four animals having completely normal histology.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume12
Edition2
StatePublished - 1982

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Magnesium
Skeletal Muscle
Dogs
Wounds and Injuries
Magnesium Deficiency
Rhabdomyolysis
Phosphorus
Muscle Cells
Chlorides
Histology
Potassium
Seizures
Necrosis
Sodium
Diet
Calcium
Biopsy
Muscles

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cronin, R. E., Ferguson, E. R., Shannon, W. A., & Knochel, J. P. (1982). Skeletal muscle injury after magnesium depletion in the dog. In American Journal of Physiology - Renal Fluid and Electrolyte Physiology (2 ed., Vol. 12)

Skeletal muscle injury after magnesium depletion in the dog. / Cronin, R. E.; Ferguson, E. R.; Shannon, W. A.; Knochel, J. P.

American Journal of Physiology - Renal Fluid and Electrolyte Physiology. Vol. 12 2. ed. 1982.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cronin, RE, Ferguson, ER, Shannon, WA & Knochel, JP 1982, Skeletal muscle injury after magnesium depletion in the dog. in American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 2 edn, vol. 12.
Cronin RE, Ferguson ER, Shannon WA, Knochel JP. Skeletal muscle injury after magnesium depletion in the dog. In American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 2 ed. Vol. 12. 1982
Cronin, R. E. ; Ferguson, E. R. ; Shannon, W. A. ; Knochel, J. P. / Skeletal muscle injury after magnesium depletion in the dog. American Journal of Physiology - Renal Fluid and Electrolyte Physiology. Vol. 12 2. ed. 1982.
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abstract = "Magnesium deficiency was induced in a setting of an otherwise adequate diet in adult beagle dogs. Despite the development of severe hypomagnesemia (from 1.5 ± 0.2 to 0.5 ± 0.2 meq/liter) during the 10-wk study, Mg content of skeletal muscle fell only modestly (from 3.8 ± 0.2 to 3.1 ± 0.4, P < 0.005, at 7 wk and 3.5 ± 0.4 mM/100 g FFDS, NS, at 10 wk). The most pronounced muscle compositional changes were a loss of phosphorus (from 29.5 ± 1.8 to 22.0 ± 1.6, P < 0.001, at 7 wk and 24.8 ± 2.8 mM/100 g FFDS, P < 0.001, at 10 wk) and gains of calcium (from 0.64 ± 0.11 to 0.93 ± 0.17, P < 0.05, at 7 wk, and 0.85 ± 0.26 mM/100 g FFDS, P < 0.05, at 10 wk), sodium (from 13.2 ± 2.6 to 22.9 ± 4.7, P < 0.001 at 7 wk and 17.8 ± 2.0 meq/100 g FFDS, P < 0.005, at 10 wk), and chloride (from 5.8 ± 0.8 to 8.2 ± 1.6, P < 0.001, at 7 wk and 6.8 ± 0.6 meq/100 g FFDS, P < 0.05, at 10 wk). Cellular potassium content did not change (from 35.9 ± 1.9 to 33.0 ± 4.1, NS, at 7 wk and 36.3 ± 2.0 meq/100 g FFDS, NS, at 10 wk). Muscle cell electrical hyperpolarization developed after 10 wk of Mg depletion. Convulsive seizures developed in three animals. Frank rhabdomyolysis in three animals and focal necrosis in four animals were present on terminal biopsy, with only four animals having completely normal histology.",
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N2 - Magnesium deficiency was induced in a setting of an otherwise adequate diet in adult beagle dogs. Despite the development of severe hypomagnesemia (from 1.5 ± 0.2 to 0.5 ± 0.2 meq/liter) during the 10-wk study, Mg content of skeletal muscle fell only modestly (from 3.8 ± 0.2 to 3.1 ± 0.4, P < 0.005, at 7 wk and 3.5 ± 0.4 mM/100 g FFDS, NS, at 10 wk). The most pronounced muscle compositional changes were a loss of phosphorus (from 29.5 ± 1.8 to 22.0 ± 1.6, P < 0.001, at 7 wk and 24.8 ± 2.8 mM/100 g FFDS, P < 0.001, at 10 wk) and gains of calcium (from 0.64 ± 0.11 to 0.93 ± 0.17, P < 0.05, at 7 wk, and 0.85 ± 0.26 mM/100 g FFDS, P < 0.05, at 10 wk), sodium (from 13.2 ± 2.6 to 22.9 ± 4.7, P < 0.001 at 7 wk and 17.8 ± 2.0 meq/100 g FFDS, P < 0.005, at 10 wk), and chloride (from 5.8 ± 0.8 to 8.2 ± 1.6, P < 0.001, at 7 wk and 6.8 ± 0.6 meq/100 g FFDS, P < 0.05, at 10 wk). Cellular potassium content did not change (from 35.9 ± 1.9 to 33.0 ± 4.1, NS, at 7 wk and 36.3 ± 2.0 meq/100 g FFDS, NS, at 10 wk). Muscle cell electrical hyperpolarization developed after 10 wk of Mg depletion. Convulsive seizures developed in three animals. Frank rhabdomyolysis in three animals and focal necrosis in four animals were present on terminal biopsy, with only four animals having completely normal histology.

AB - Magnesium deficiency was induced in a setting of an otherwise adequate diet in adult beagle dogs. Despite the development of severe hypomagnesemia (from 1.5 ± 0.2 to 0.5 ± 0.2 meq/liter) during the 10-wk study, Mg content of skeletal muscle fell only modestly (from 3.8 ± 0.2 to 3.1 ± 0.4, P < 0.005, at 7 wk and 3.5 ± 0.4 mM/100 g FFDS, NS, at 10 wk). The most pronounced muscle compositional changes were a loss of phosphorus (from 29.5 ± 1.8 to 22.0 ± 1.6, P < 0.001, at 7 wk and 24.8 ± 2.8 mM/100 g FFDS, P < 0.001, at 10 wk) and gains of calcium (from 0.64 ± 0.11 to 0.93 ± 0.17, P < 0.05, at 7 wk, and 0.85 ± 0.26 mM/100 g FFDS, P < 0.05, at 10 wk), sodium (from 13.2 ± 2.6 to 22.9 ± 4.7, P < 0.001 at 7 wk and 17.8 ± 2.0 meq/100 g FFDS, P < 0.005, at 10 wk), and chloride (from 5.8 ± 0.8 to 8.2 ± 1.6, P < 0.001, at 7 wk and 6.8 ± 0.6 meq/100 g FFDS, P < 0.05, at 10 wk). Cellular potassium content did not change (from 35.9 ± 1.9 to 33.0 ± 4.1, NS, at 7 wk and 36.3 ± 2.0 meq/100 g FFDS, NS, at 10 wk). Muscle cell electrical hyperpolarization developed after 10 wk of Mg depletion. Convulsive seizures developed in three animals. Frank rhabdomyolysis in three animals and focal necrosis in four animals were present on terminal biopsy, with only four animals having completely normal histology.

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