Skeletal muscle loss is associated with TNF mediated insufficient skeletal myogenic activation after burn

Juquan Song, Melody R. Saeman, Jana De Libero, Steven E. Wolf

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Muscle loss accompanies severe burn; in this hyper-catabolic state, muscle undergoes atrophy through protein degradation and disuse. Muscle volume is related to the relative rates of cellular degradation and myogenesis. We hypothesize that muscle atrophy after injury is in part because of insufficient myogenesis associated with the hyperinflammatory response. The aim of this study was to investigate the role of skeletalmyogenesis and muscle cell homeostasis in response to severe burn. Twenty-eight male C57BL6 mice received 25% TBSA scald. Gluteus muscle from these animals was analyzed at days 1, 3, 7, and 14 after injury. Six additional animals without burn served as controls.We showed muscle wet weight and protein content decreased at days 3 and 7 after burn, with elevated tumor necrosis factor (TNF) mRNA expression (P

Original languageEnglish (US)
Pages (from-to)479-486
Number of pages8
JournalShock
Volume44
Issue number5
DOIs
StatePublished - 2015

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Skeletal Muscle
Tumor Necrosis Factor-alpha
Muscles
Muscular Atrophy
Muscle Development
Wounds and Injuries
Muscle Cells
Proteolysis
Homeostasis
Weights and Measures
Messenger RNA
Proteins

Keywords

  • Burn
  • Gluteus muscles
  • Mouse
  • Myogenic regulatory factors (MRFs)
  • satellite cell

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

Cite this

Skeletal muscle loss is associated with TNF mediated insufficient skeletal myogenic activation after burn. / Song, Juquan; Saeman, Melody R.; De Libero, Jana; Wolf, Steven E.

In: Shock, Vol. 44, No. 5, 2015, p. 479-486.

Research output: Contribution to journalArticle

Song, Juquan ; Saeman, Melody R. ; De Libero, Jana ; Wolf, Steven E. / Skeletal muscle loss is associated with TNF mediated insufficient skeletal myogenic activation after burn. In: Shock. 2015 ; Vol. 44, No. 5. pp. 479-486.
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