Skin of the dorsal aspect of human hands and fingers possesses an active vasodilator system

J. M. Johnson, P. E. Pergola, F. K. Liao, D. L. Kellogg, C. G. Crandall

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

To test for an active vasodilator system in human hand and finger skin, seven subjects had a small area of dorsal hand, palm, or dorsal finger pretreated with bretylium (BT) to block adrenergic vasoconstriction. Skin blood flow was monitored at a BT-treated site, a comparable untreated site, and the forearm by laser-Doppler flowmetry. Cutaneous vascular conductance (CVC) was evaluated from the ratio of blood flow to arterial pressure. Body cooling, to evaluate vasoconstrictor system blockade, caused CVC at untreated sites of forearm, palm, dorsal hand, and dorsal finger to fall by 45 ± 4, 85 ± 5, 51 ± 9, and 63 ± 7%, respectively (all P < 0.05). At BT treated sites of palm, dorsal hand, and dorsal finger, reductions in CVC were only 13 ± 3, 2 ± 18, and 13 ± 4%, respectively (dorsal hand not significant, others P < 0.05). With body heating, increases in CVC at untreated sites of forearm, palm, dorsal hand, and dorsal finger were 881 ± 165,779 ± 368, 423 ± 115, and 1,430 ± 716%, respectively (all P < 0.05). At BT-treated sites of palm, dorsal hand, and dorsal finger, increases were 35 ± 15, 342 ± 107, and 343 ± 34%, respectively (palm not significant, others P < 0.05). Increased CVC at the palm began after 1.2 ± 0.2 min of heating, significantly earlier than forearm (11.8 ± 2.5 min), dorsal hand (16.4 ± 3.4 min), or dorsal finger (15.6 ± 3.6 min), which did not differ significantly from one another. These findings indicate that, unlike the traditional description, the dorsal hand and fingers have an active vasodilator system. We found no evidence for such a system in palmar skin.

Original languageEnglish (US)
Pages (from-to)948-954
Number of pages7
JournalJournal of Applied Physiology
Volume78
Issue number3
StatePublished - 1995

Fingerprint

Vasodilator Agents
Fingers
Hand
Skin
Blood Vessels
Forearm
Heating
Laser-Doppler Flowmetry
Vasoconstrictor Agents
Vasoconstriction
Adrenergic Agents
Arterial Pressure
bretylium

Keywords

  • bretylium
  • cold stress
  • heat stress
  • iontophoresis
  • laser-Doppler flowmetry
  • neurogenic vasodilation
  • peripheral circulation
  • reflex control
  • skin blood flow
  • vasoconstriction
  • vasodilation

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Skin of the dorsal aspect of human hands and fingers possesses an active vasodilator system. / Johnson, J. M.; Pergola, P. E.; Liao, F. K.; Kellogg, D. L.; Crandall, C. G.

In: Journal of Applied Physiology, Vol. 78, No. 3, 1995, p. 948-954.

Research output: Contribution to journalArticle

Johnson, J. M. ; Pergola, P. E. ; Liao, F. K. ; Kellogg, D. L. ; Crandall, C. G. / Skin of the dorsal aspect of human hands and fingers possesses an active vasodilator system. In: Journal of Applied Physiology. 1995 ; Vol. 78, No. 3. pp. 948-954.
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abstract = "To test for an active vasodilator system in human hand and finger skin, seven subjects had a small area of dorsal hand, palm, or dorsal finger pretreated with bretylium (BT) to block adrenergic vasoconstriction. Skin blood flow was monitored at a BT-treated site, a comparable untreated site, and the forearm by laser-Doppler flowmetry. Cutaneous vascular conductance (CVC) was evaluated from the ratio of blood flow to arterial pressure. Body cooling, to evaluate vasoconstrictor system blockade, caused CVC at untreated sites of forearm, palm, dorsal hand, and dorsal finger to fall by 45 ± 4, 85 ± 5, 51 ± 9, and 63 ± 7{\%}, respectively (all P < 0.05). At BT treated sites of palm, dorsal hand, and dorsal finger, reductions in CVC were only 13 ± 3, 2 ± 18, and 13 ± 4{\%}, respectively (dorsal hand not significant, others P < 0.05). With body heating, increases in CVC at untreated sites of forearm, palm, dorsal hand, and dorsal finger were 881 ± 165,779 ± 368, 423 ± 115, and 1,430 ± 716{\%}, respectively (all P < 0.05). At BT-treated sites of palm, dorsal hand, and dorsal finger, increases were 35 ± 15, 342 ± 107, and 343 ± 34{\%}, respectively (palm not significant, others P < 0.05). Increased CVC at the palm began after 1.2 ± 0.2 min of heating, significantly earlier than forearm (11.8 ± 2.5 min), dorsal hand (16.4 ± 3.4 min), or dorsal finger (15.6 ± 3.6 min), which did not differ significantly from one another. These findings indicate that, unlike the traditional description, the dorsal hand and fingers have an active vasodilator system. We found no evidence for such a system in palmar skin.",
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AU - Johnson, J. M.

AU - Pergola, P. E.

AU - Liao, F. K.

AU - Kellogg, D. L.

AU - Crandall, C. G.

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AB - To test for an active vasodilator system in human hand and finger skin, seven subjects had a small area of dorsal hand, palm, or dorsal finger pretreated with bretylium (BT) to block adrenergic vasoconstriction. Skin blood flow was monitored at a BT-treated site, a comparable untreated site, and the forearm by laser-Doppler flowmetry. Cutaneous vascular conductance (CVC) was evaluated from the ratio of blood flow to arterial pressure. Body cooling, to evaluate vasoconstrictor system blockade, caused CVC at untreated sites of forearm, palm, dorsal hand, and dorsal finger to fall by 45 ± 4, 85 ± 5, 51 ± 9, and 63 ± 7%, respectively (all P < 0.05). At BT treated sites of palm, dorsal hand, and dorsal finger, reductions in CVC were only 13 ± 3, 2 ± 18, and 13 ± 4%, respectively (dorsal hand not significant, others P < 0.05). With body heating, increases in CVC at untreated sites of forearm, palm, dorsal hand, and dorsal finger were 881 ± 165,779 ± 368, 423 ± 115, and 1,430 ± 716%, respectively (all P < 0.05). At BT-treated sites of palm, dorsal hand, and dorsal finger, increases were 35 ± 15, 342 ± 107, and 343 ± 34%, respectively (palm not significant, others P < 0.05). Increased CVC at the palm began after 1.2 ± 0.2 min of heating, significantly earlier than forearm (11.8 ± 2.5 min), dorsal hand (16.4 ± 3.4 min), or dorsal finger (15.6 ± 3.6 min), which did not differ significantly from one another. These findings indicate that, unlike the traditional description, the dorsal hand and fingers have an active vasodilator system. We found no evidence for such a system in palmar skin.

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KW - reflex control

KW - skin blood flow

KW - vasoconstriction

KW - vasodilation

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